Enhancing brown fat with NFIA

被引：3
|
作者：
Shapira, Suzanne N. [1 ]
Seale, Patrick [1 ]
机构：
[1] Univ Penn, Inst Diabet Obes & Metab, Dept Cell & Dev Biol, Smilow Ctr Translat Res,Perelman Sch Med, Philadelphia, PA 19104 USA
来源：
NATURE CELL BIOLOGY | 2017年 / 19卷 / 09期
关键词：
ADIPOSE-TISSUE; GENE-EXPRESSION; TRANSCRIPTION;
D O I：
10.1038/ncb3591
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.
引用
收藏
页码：1006 / 1007
页数：2
相关论文
共 50 条
  • [21] CATECHOLAMINES IN BROWN FAT
    WIRSEN, C
    HAMBERGER, B
    NATURE, 1967, 214 (5088) : 625 - +
  • [22] The brain and brown fat
    Contreras, Cristina
    Gonzalez, Francisco
    Ferno, Johan
    Dieguez, Carlos
    Rahmouni, Kamal
    Nogueiras, Ruben
    Lopez, Miguel
    ANNALS OF MEDICINE, 2015, 47 (02) : 150 - 168
  • [23] TUMOURS OF BROWN FAT
    SHUTE, D
    CANADIAN MEDICAL ASSOCIATION JOURNAL, 1954, 71 (05) : 484 - 485
  • [24] SUBCUTANEOUS FAT NECROSIS AND BROWN FAT DEFICIENCY
    TAIEB, A
    DOUARD, D
    MALEVILLE, J
    JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY, 1987, 16 (03) : 624 - 625
  • [25] Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat
    Xue, Bingzhong
    Rim, Jong-Seop
    Hogan, Jessica C.
    Coulter, Ann A.
    Koza, Robert A.
    Kozak, Leslie P.
    JOURNAL OF LIPID RESEARCH, 2007, 48 (01) : 41 - 51
  • [26] How brown is brown fat that we can see?
    Kolonin, Mikhail G.
    ADIPOCYTE, 2014, 3 (02) : 155 - 159
  • [27] Brown fat: muscle undercover?
    Francesca Cesari
    Nature Reviews Molecular Cell Biology, 2008, 9 : 742 - 743
  • [28] CELL CULTURES OF BROWN FAT
    MASTERS, E
    ANATOMICAL RECORD, 1964, 148 (02): : 309 - &
  • [29] FETAL KIDNEY AND BROWN FAT
    MERKLIN, RJ
    ANATOMICAL RECORD, 1974, 178 (02): : 415 - 415
  • [30] THERMOGENESIS OF BROWN FAT IN HIBERNATOR
    SMITH, RE
    HOCK, RJ
    FEDERATION PROCEEDINGS, 1963, 22 (02) : 341 - &
12345