Enhancing brown fat with NFIA

被引：3

作者：

Shapira, Suzanne N. ^{[1
]}

Seale, Patrick ^{[1
]}

机构：

[1] Univ Penn, Inst Diabet Obes & Metab, Dept Cell & Dev Biol, Smilow Ctr Translat Res,Perelman Sch Med, Philadelphia, PA 19104 USA

来源：

NATURE CELL BIOLOGY | 2017年 / 19卷 / 09期

关键词：

ADIPOSE-TISSUE; GENE-EXPRESSION; TRANSCRIPTION;

D O I：

10.1038/ncb3591

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Brown adipose tissue is a key metabolic organ that oxidizes fatty acids and glucose to generate heat. Through epigenomic analyses of multiple adipose depots, the transcription factor nuclear factor I-A (NFIA) is now shown to drive the brown fat genetic program through binding to lineage-specific cis-regulatory elements.

引用

页码：1006 / 1007

页数：2

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