Sepsis leads to thyroid impairment and dysfunction in rat model

被引：11
|
作者：
Lin, Xingsheng [1 ,2 ]
Shi, Songjing [2 ]
Shi, Songchang [1 ]
机构：
[1] Fujian Prov South Branch Hosp, Dept Intens Care Med 1, 516 South Jinrong Rd, Fuzhou, Fujian, Peoples R China
[2] Fujian Prov Hosp, Dept Intens Care Med 2, Fuzhou, Fujian, Peoples R China
来源：
TISSUE & CELL | 2016年 / 48卷 / 05期
关键词：
Sepsis; Thyroid hormone; Caspase-3; TUNEL assay; Rat model; CECAL LIGATION; ANIMAL-MODELS; EPIDEMIOLOGY; SURVIVAL; AXIS;
D O I：
10.1016/j.tice.2016.07.001
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Sepsis was a systemic response to a local infection. Apoptosis was observed in the experimental sepsis. In this study, cecal ligation and puncture (CLP)-induced sepsis was established in rats. We found that sepsis decreased thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free T3 (fT3), and free T4 (fT4). Besides, we detected the increasing expression level of Caspase-3 and increasing ratio of TUNEL positive cells in the thyroid after sepsis. Furthermore, a series of pathological ultrastructural changes were observed in thyroid follicular epithelial cells by CLP-induced sepsis. This study established a sepsis animal model and provided the cellular and molecular basis for decoding the pathological mechanism in thyroid with the occurrence of sepsis. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：511 / 515
页数：5
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