Sepsis leads to thyroid impairment and dysfunction in rat model

被引：11

作者：

Lin, Xingsheng ^{[1
,2
]}

Shi, Songjing ^{[2
]}

Shi, Songchang ^{[1
]}

机构：

[1] Fujian Prov South Branch Hosp, Dept Intens Care Med 1, 516 South Jinrong Rd, Fuzhou, Fujian, Peoples R China

[2] Fujian Prov Hosp, Dept Intens Care Med 2, Fuzhou, Fujian, Peoples R China

来源：

TISSUE & CELL | 2016年 / 48卷 / 05期

关键词：

Sepsis; Thyroid hormone; Caspase-3; TUNEL assay; Rat model; CECAL LIGATION; ANIMAL-MODELS; EPIDEMIOLOGY; SURVIVAL; AXIS;

D O I：

10.1016/j.tice.2016.07.001

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Sepsis was a systemic response to a local infection. Apoptosis was observed in the experimental sepsis. In this study, cecal ligation and puncture (CLP)-induced sepsis was established in rats. We found that sepsis decreased thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free T3 (fT3), and free T4 (fT4). Besides, we detected the increasing expression level of Caspase-3 and increasing ratio of TUNEL positive cells in the thyroid after sepsis. Furthermore, a series of pathological ultrastructural changes were observed in thyroid follicular epithelial cells by CLP-induced sepsis. This study established a sepsis animal model and provided the cellular and molecular basis for decoding the pathological mechanism in thyroid with the occurrence of sepsis. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：511 / 515

页数：5

共 50 条

[21] Sepsis otopathy: experimental sepsis leads to significant hearing impairment due to apoptosis and glutamate excitotoxicity in murine cochlea
Schmutzhard, Joachim
Glueckert, Rudolf
Pritz, Christian
Blumer, Michael J. F.
Bitsche, Mario
Lackner, Peter
Fille, Manfred
Riechelmann, Herbert
Harkamp, Matthias
Sitthisak, Thongrong
Schrott-Fischer, Annelies
DISEASE MODELS & MECHANISMS, 2013, 6 (03) : 745 - 754
[22] THE ROLE OF ASTROCYTES IN THE NERVOUS SYSTEM DYSFUNCTION, SEPSIS INDUCED MEMORY IMPAIRMENT
Yamada, Marina
Chiba, Tomohiro
Matsuda, Akihisa
Aiso, Sadakazu
Masuno, Tomohiko
Mastumoto, Hisashi
Yokota, Hiroyuki
Miyashita, Masao
SHOCK, 2016, 46 (04): : 45 - 45
[23] Mitochondrial dysfunction, bioenergetic impairment, and metabolic down-regulation in sepsis
Levy, Richard J.
SHOCK, 2007, 28 (01): : 24 - 28
[24] Thyroid dysfunction modulates glucoregulatory mechanism in rat
Chakrabarti, Sudipta
Guria, Srikanta
Samanta, Ipsita
Das, Madhusudan
INDIAN JOURNAL OF EXPERIMENTAL BIOLOGY, 2007, 45 (06) : 549 - 553
[25] KW-2449 Ameliorates Cardiac Dysfunction in a Rat Model of Sepsis-Induced Cardiomyopathy
Chen, Jie
Zhang, Wei-jian
Liu, Xiao-yu
Hu, Tian-peng
Gao, Nan
Li, Zhong-hao
Wang, Yu
Zhang, Guo-qiang
INFLAMMATION, 2025,
[26] Assessment of inflammatory markers and mitochondrial factors in a rat model of sepsis-induced myocardial dysfunction
Zeng, Xiao-Mei
Liu, De-Hong
Han, Yong
Huang, Zhi-Qiang
Zhang, Ji-Wen
Huang, Qun
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH, 2020, 12 (03): : 901 - 911
[27] Change Level of TRAb in Newborn Leads to Thyroid Dysfunction - Case Report
Sawicka, Beata
Borysewicz-Sanczyk, Hanna
Bossowski, Artur
HORMONE RESEARCH IN PAEDIATRICS, 2016, 86 : 358 - 359
[28] Dysfunction in motility and apoptotic cell recognition leads to the impairment of microglial phagocytosis in epilepsy
Diaz-Aparicio, I.
Abiega, O.
Beccari, S.
Nadjar, A.
Laye, S.
Leyrolle, Q.
Domercq, M.
Perez-Samartin, A.
Sanchez-Zafra, V.
Paris, I.
Valero, J.
Savage, J. C.
Hui, C. W.
Tremblay, M. -E.
Vivanco, M. D. M.
Matute, C.
Maletic-Savatic, M.
Encinas, J. M.
Sierra, A.
GLIA, 2017, 65 : E137 - E138
[29] Mitochondrial dysfunction in a rodent model of sepsis and multi-organ dysfunction
Brealey, DA
Karyampudi, S
Taylor, V
Stidwill, R
Singer, M
BRITISH JOURNAL OF ANAESTHESIA, 2003, 90 (04) : 541P - 541P
[30] Endothelin-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction
Latha Diwakar
Ruturaj Gowaikar
Keerthana Chithanathan
Barathan Gnanabharathi
Deepika Singh Tomar
Vijayalakshmi Ravindranath
Scientific Reports, 11

← 1 2 3 4 5 →