Sepsis leads to thyroid impairment and dysfunction in rat model

被引：11
|
作者：
Lin, Xingsheng [1 ,2 ]
Shi, Songjing [2 ]
Shi, Songchang [1 ]
机构：
[1] Fujian Prov South Branch Hosp, Dept Intens Care Med 1, 516 South Jinrong Rd, Fuzhou, Fujian, Peoples R China
[2] Fujian Prov Hosp, Dept Intens Care Med 2, Fuzhou, Fujian, Peoples R China
来源：
TISSUE & CELL | 2016年 / 48卷 / 05期
关键词：
Sepsis; Thyroid hormone; Caspase-3; TUNEL assay; Rat model; CECAL LIGATION; ANIMAL-MODELS; EPIDEMIOLOGY; SURVIVAL; AXIS;
D O I：
10.1016/j.tice.2016.07.001
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Sepsis was a systemic response to a local infection. Apoptosis was observed in the experimental sepsis. In this study, cecal ligation and puncture (CLP)-induced sepsis was established in rats. We found that sepsis decreased thyroid hormone levels, including triiodothyronine (T3), thyroxine (T4), free T3 (fT3), and free T4 (fT4). Besides, we detected the increasing expression level of Caspase-3 and increasing ratio of TUNEL positive cells in the thyroid after sepsis. Furthermore, a series of pathological ultrastructural changes were observed in thyroid follicular epithelial cells by CLP-induced sepsis. This study established a sepsis animal model and provided the cellular and molecular basis for decoding the pathological mechanism in thyroid with the occurrence of sepsis. (C) 2016 Elsevier Ltd. All rights reserved.
引用
收藏
页码：511 / 515
页数：5
相关论文
共 50 条
  • [31] Endothelin-1 mediated vasoconstriction leads to memory impairment and synaptic dysfunction
    Diwakar, Latha
    Gowaikar, Ruturaj
    Chithanathan, Keerthana
    Gnanabharathi, Barathan
    Tomar, Deepika Singh
    Ravindranath, Vijayalakshmi
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [32] STATINS PROTECTS COGNITIVE IMPAIRMENT IN ANIMAL MODEL OF SEPSIS
    Bozza, F. A.
    Reis, P.
    Alexandre, P. C.
    Pitombo, M. M.
    Castro-Faria-Neto, H. C.
    INTENSIVE CARE MEDICINE, 2012, 38 : S125 - S125
  • [33] Effect of polymyxin B-immobilized fiber hemoperfusion on respiratory impairment, hepatocellular dysfunction, and leucopenia in a neonatal sepsis model
    Mohamed Hamed Hussein
    Ghada A. Daoud
    Hiroki Kakita
    Shin Kato
    Tatenobu Goto
    Michi Kamei
    Kenji Goto
    Yasuhiko Ozaki
    Tetsuya Ito
    Sumio Fukuda
    Ineko Kato
    Satoshi Suzuki
    Takashi Hashimoto
    Hajime Togari
    Pediatric Surgery International, 2010, 26 : 187 - 193
  • [34] Effect of polymyxin B-immobilized fiber hemoperfusion on respiratory impairment, hepatocellular dysfunction, and leucopenia in a neonatal sepsis model
    Hussein, Mohamed Hamed
    Daoud, Ghada A.
    Kakita, Hiroki
    Kato, Shin
    Goto, Tatenobu
    Kamei, Michi
    Goto, Kenji
    Ozaki, Yasuhiko
    Ito, Tetsuya
    Fukuda, Sumio
    Kato, Ineko
    Suzuki, Satoshi
    Hashimoto, Takashi
    Togari, Hajime
    PEDIATRIC SURGERY INTERNATIONAL, 2010, 26 (02) : 187 - 193
  • [35] DIRECT HEMOPERFUSION IN RAT SEPSIS MODEL
    KOBAYASHI, H
    ODAKA, M
    HIRASAWA, H
    OHTAKE, Y
    ODA, S
    KOBAYASHI, S
    SATOH, H
    ARTIFICIAL ORGANS, 1984, 8 (02) : 244 - 244
  • [36] Effects of melatonin in a rat model of sepsis
    Lowes, D. A.
    Webster, N. R.
    Galley, H. F.
    BRITISH JOURNAL OF ANAESTHESIA, 2011, 107 (05) : 834P - 834P
  • [37] PAD4 Deficiency Leads to Decreased Organ Dysfunction and Improved Survival in a Dual Insult Model of Hemorrhagic Shock and Sepsis
    Biron, Bethany M.
    Chung, Chun-Shiang
    Chen, Yaping
    Wilson, Zachary
    Fallon, Eleanor A.
    Reichner, Jonathan S.
    Ayala, Alfred
    JOURNAL OF IMMUNOLOGY, 2018, 200 (05): : 1817 - 1828
  • [38] Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model
    Kowalewska, Paulina M.
    Piazza, Justin E.
    Milkovich, Stephanie L.
    Sove, Richard J.
    Wang, Lin
    Whitehead, Shawn N.
    Ellis, Christopher G.
    SCIENTIFIC REPORTS, 2022, 12 (01)
  • [39] Spectroscopy detects skeletal muscle microvascular dysfunction during onset of sepsis in a rat fecal peritonitis model
    Paulina M. Kowalewska
    Justin E. Kowalewski
    Stephanie L. Milkovich
    Richard J. Sové
    Lin Wang
    Shawn N. Whitehead
    Christopher G. Ellis
    Scientific Reports, 12
  • [40] P2X(7) receptor antagonism ameliorates renal dysfunction in a rat model of sepsis
    Arulkumaran, Nishkantha
    Sixma, Marije L.
    Pollen, Sean
    Ceravola, Elias
    Jentho, Elisa
    Prendecki, Maria
    Bass, Paul S.
    Tam, Frederick. W. K.
    Unwin, Robert J.
    Singer, Mervyn
    PHYSIOLOGICAL REPORTS, 2018, 6 (05):
12345