Comparator-based gene regulatory network designs for control of expression

被引：1
|
作者：
Kazemi, J. [1 ]
Ozgoli, S. [1 ]
Ingalls, B. P. [2 ]
机构：
[1] Tarbiat Modares Univ, Sch Elect & Comp Engn, Adv Control Syst Lab, Tehran, Iran
[2] Univ Waterloo, Dept Appl Math, Waterloo, ON N2L 3G1, Canada
来源：
IFAC PAPERSONLINE | 2018年 / 51卷 / 19期
关键词：
Synthetic Biology; Feedback Control; Relay Switch; Synthetic Genetic Comparator; ROBUST PERFECT ADAPTATION; INTEGRAL FEEDBACK-CONTROL; IMPLEMENTATION; CELLS;
D O I：
10.1016/j.ifacol.2018.09.031
中图分类号：
TP [自动化技术、计算机技术];
学科分类号：
0812 ;
摘要：
We present comparator-based gene network designs for feedback control of the concentration of gene products. Two gene circuit designs are proposed, each of which compares concentrations of an input transcription factor (the reference input) with the protein product of a target gene (the process output). These designs employ a genetic relay switch and a shifted subtractor as components of a discrete comparator circuit and a bistable comparator circuit, respectively. Numerical simulation results illustrate the potential effectiveness of the designed controllers. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.
引用
收藏
页码：38 / 41
页数：4
相关论文
共 50 条
  • [31] Comparator-based binary-search ADC architectures for UWB receivers
    Taimur Rabuske
    Fabio Rabuske
    Jorge Fernandes
    Cesar Rodrigues
    Diogo Brito
    Analog Integrated Circuits and Signal Processing, 2013, 77 : 471 - 482
  • [32] Pipeline Power Reduction through Single Comparator-based Clock Gating
    Wang, Wei
    Tsao, Yu-Chi
    Choi, Ken
    Park, SeongMo
    Chung, Moo-Kyoung
    2009 INTERNATIONAL SOC DESIGN CONFERENCE (ISOCC 2009), 2009, : 480 - +
  • [33] Comparator-based circuits easily shift voltage level, flip polarity
    Maxim Integrated Products Inc., Sunnyvale, CA, United States
    Electron Des, 2006, 13 (59-60):
  • [34] Current Comparator-Based Reconfigurable Adder and Multiplier on Hybrid Memristive Crossbar
    Mondal, Manobendra Nath
    Sur-Kolay, Susmita
    Bhattacharya, Bhargab B.
    2020 IEEE COMPUTER SOCIETY ANNUAL SYMPOSIUM ON VLSI (ISVLSI 2020), 2020, : 494 - 499
  • [35] High-accuracy Comparator-Based Switched-Capacitor structure
    Mortazavi, Seyed Yahya
    Nabavi, Abdolreza
    Amiri, Parviz
    IEICE ELECTRONICS EXPRESS, 2010, 7 (05): : 352 - 359
  • [36] Comparator-based binary-search ADC architectures for UWB receivers
    Rabuske, Taimur
    Rabuske, Fabio
    Fernandes, Jorge
    Rodrigues, Cesar
    Brito, Diogo
    ANALOG INTEGRATED CIRCUITS AND SIGNAL PROCESSING, 2013, 77 (03) : 471 - 482
  • [37] Pipelined SAR with Comparator-Based Switch-Capacitor Residue Amplification
    Torres, Frank Sill
    Kohler Marra Pinto, Pedro Henrique
    2016 IEEE 7TH LATIN AMERICAN SYMPOSIUM ON CIRCUITS & SYSTEMS (LASCAS), 2016, : 119 - 122
  • [38] A 300-mV Auto Shutdown Comparator-Based Continuous Time ΔΣ Modulator
    Somappa, Laxmeesha
    Baghini, Maryam Shojaei
    IEEE TRANSACTIONS ON VERY LARGE SCALE INTEGRATION (VLSI) SYSTEMS, 2020, 28 (08) : 1920 - 1924
  • [39] Comparator-Based Switched-Capacitor Pipelined ADC with Background Offset Calibration
    Jang, Ji-Eun
    2011 IEEE INTERNATIONAL SYMPOSIUM ON CIRCUITS AND SYSTEMS (ISCAS), 2011, : 253 - 256
  • [40] A STABLE AND ACCURATE CURRENT COMPARATOR-BASED QUADRATURE CURRENT REFERENCE FOR POWER FREQUENCIES
    SO, E
    MOORE, WJM
    IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT, 1982, 31 (01) : 43 - 46
12345