Comparator-based gene regulatory network designs for control of expression

被引：1

作者：

Kazemi, J. ^{[1
]}

Ozgoli, S. ^{[1
]}

Ingalls, B. P. ^{[2
]}

机构：

[1] Tarbiat Modares Univ, Sch Elect & Comp Engn, Adv Control Syst Lab, Tehran, Iran

[2] Univ Waterloo, Dept Appl Math, Waterloo, ON N2L 3G1, Canada

来源：

IFAC PAPERSONLINE | 2018年 / 51卷 / 19期

关键词：

Synthetic Biology; Feedback Control; Relay Switch; Synthetic Genetic Comparator; ROBUST PERFECT ADAPTATION; INTEGRAL FEEDBACK-CONTROL; IMPLEMENTATION; CELLS;

D O I：

10.1016/j.ifacol.2018.09.031

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

We present comparator-based gene network designs for feedback control of the concentration of gene products. Two gene circuit designs are proposed, each of which compares concentrations of an input transcription factor (the reference input) with the protein product of a target gene (the process output). These designs employ a genetic relay switch and a shifted subtractor as components of a discrete comparator circuit and a bistable comparator circuit, respectively. Numerical simulation results illustrate the potential effectiveness of the designed controllers. (C) 2018, IFAC (International Federation of Automatic Control) Hosting by Elsevier Ltd. All rights reserved.

引用

页码：38 / 41

页数：4

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