Synthesis of Indoles by Conjugate Addition and Ligand-Free Copper-Catalyzed Intramolecular Arylation of Activated Acetylenes with o-Haloanilines

被引：27
|
作者：
Gao, Detian [1 ]
Parvez, Masood [1 ]
Back, Thomas G. [1 ]
机构：
[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada
来源：
CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 48期
基金：
加拿大自然科学与工程研究理事会;
关键词：
acetylenes; copper; cyclization; indoles; REACTION SEQUENCE; SULFONES; HETEROANNULATION; CYCLOADDITIONS; IODOANILINES; CYCLIZATIONS; DERIVATIVES; 1-ALKYNES; OXIDATION; PRODUCTS;
D O I：
10.1002/chem.201002628
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Air and water welcome-ligands need not apply! A simple and efficient new synthesis of variously functionalized and substituted indoles was achieved by the addition and copper-catalyzed coupling of N-formyl-o-haloanilines with acetylenic sulfones, esters and ketones (see scheme; EWG=electron-withdrawing group). The reaction employs copper(II) acetate under ligand-free conditions without the need for exclusion of air and moisture. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
引用
收藏
页码：14281 / 14284
页数：4
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