Domino Ligand-Free Copper-Catalyzed Synthesis of Polysubstituted Indoles

被引：29
|
作者：
Ali, Md Ashif [1 ]
Punniyamurthy, Tharmalingam [1 ]
机构：
[1] Indian Inst Technol Guwahati, Dept Chem, Gauhati 781039, India
来源：
SYNLETT | 2011年 / 05期
关键词：
Cu(2)O; indoles; cesium carbonate; 1,3-dicarbonyl compounds; 2-haloanilines; NONREARRANGED MONOTERPENOID UNIT; CROSS-COUPLING REACTIONS; 2,3-DISUBSTITUTED INDOLES; N-ARYLATION; NATURAL-PRODUCTS; ARYL BROMIDES; ONE-POT; CYCLIZATION; ALKALOIDS; MILD;
D O I：
10.1055/s-0030-1259548
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The synthesis of polysubstituted indoles is described by the domino reaction of 2-haloanilines and 1,3-dicarbonyl compounds, 1,3-diketones, beta-keto esters and beta-keto amides, using copper catalysis under ligand-free conditions. The protocol provides a simple, general and atom economical process for the synthesis of substituted indoles at moderate temperature.
引用
收藏
页码：623 / 626
页数：4
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