Synthesis of Indoles by Conjugate Addition and Ligand-Free Copper-Catalyzed Intramolecular Arylation of Activated Acetylenes with o-Haloanilines

被引：27

作者：

Gao, Detian ^{[1
]}

Parvez, Masood ^{[1
]}

Back, Thomas G. ^{[1
]}

机构：

[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2010年 / 16卷 / 48期

基金：

加拿大自然科学与工程研究理事会;

关键词：

acetylenes; copper; cyclization; indoles; REACTION SEQUENCE; SULFONES; HETEROANNULATION; CYCLOADDITIONS; IODOANILINES; CYCLIZATIONS; DERIVATIVES; 1-ALKYNES; OXIDATION; PRODUCTS;

D O I：

10.1002/chem.201002628

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Air and water welcome-ligands need not apply! A simple and efficient new synthesis of variously functionalized and substituted indoles was achieved by the addition and copper-catalyzed coupling of N-formyl-o-haloanilines with acetylenic sulfones, esters and ketones (see scheme; EWG=electron-withdrawing group). The reaction employs copper(II) acetate under ligand-free conditions without the need for exclusion of air and moisture. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：14281 / 14284

页数：4

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