Thymoquinone: A small molecule from nature with high therapeutic potential

被引：33
|
作者：
Malik, Safiya [1 ]
Singh, Amardeep [1 ]
Negi, Poonam [1 ]
Kapoor, Vijay Kumar [1 ]
机构：
[1] Shoolini Univ, Sch Pharmaceut Sci, Solan 173212, India
来源：
DRUG DISCOVERY TODAY | 2021年 / 26卷 / 11期
关键词：
Thymoquinone; Analogs; Biological activities; Clinical trials; Preclinical studies; Molecular mechanism; Nanotechnology; NF-KAPPA-B; OXIDATIVE STRESS; RHEUMATOID-ARTHRITIS; INDUCED INFLAMMATION; BREAST-CANCER; TNF-ALPHA; EXPRESSION; MODEL; INHIBITION; PROTECTS;
D O I：
10.1016/j.drudis.2021.07.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Thymoquinone (TQ; 2-isopropyl-5-methylbenzo-1, 4-quinone), the main active constituent of Nigella sativa, has been proven to have great therapeutic properties in numerous in vivo and in vitro models. Nevertheless, this molecule is not yet in clinical trials, largely because of its poor bioavailability and hydrophobicity. This review examines the different activities of TQ, as well as various combination therapies, nanotechnologies and clinical trials involving TQ. The TQ nanoparticle formulation shows better bioavailability than free TQ, and it is time for clinical trials of these formulations to realize the potential of TQ as a therapeutic.
引用
收藏
页码：2716 / 2725
页数：10
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