Thymoquinone: A small molecule from nature with high therapeutic potential

被引：33

作者：

Malik, Safiya ^{[1
]}

Singh, Amardeep ^{[1
]}

Negi, Poonam ^{[1
]}

Kapoor, Vijay Kumar ^{[1
]}

机构：

[1] Shoolini Univ, Sch Pharmaceut Sci, Solan 173212, India

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 11期

关键词：

Thymoquinone; Analogs; Biological activities; Clinical trials; Preclinical studies; Molecular mechanism; Nanotechnology; NF-KAPPA-B; OXIDATIVE STRESS; RHEUMATOID-ARTHRITIS; INDUCED INFLAMMATION; BREAST-CANCER; TNF-ALPHA; EXPRESSION; MODEL; INHIBITION; PROTECTS;

D O I：

10.1016/j.drudis.2021.07.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thymoquinone (TQ; 2-isopropyl-5-methylbenzo-1, 4-quinone), the main active constituent of Nigella sativa, has been proven to have great therapeutic properties in numerous in vivo and in vitro models. Nevertheless, this molecule is not yet in clinical trials, largely because of its poor bioavailability and hydrophobicity. This review examines the different activities of TQ, as well as various combination therapies, nanotechnologies and clinical trials involving TQ. The TQ nanoparticle formulation shows better bioavailability than free TQ, and it is time for clinical trials of these formulations to realize the potential of TQ as a therapeutic.

引用

页码：2716 / 2725

页数：10

共 50 条

[21] Identification of an aspirin-derived small molecule as a potential therapeutic for colorectal cancer
Karelia, Deepkamal
Pandey, Manoj
Plano, Daniel
Narayan, Satya
Jani, Jitesh
Sharma, Jay
Amin, Shantu
Sharma, Arun K.
CANCER RESEARCH, 2015, 75
[22] SMALL-MOLECULE PENDRIN INHIBITORS AS A POTENTIAL THERAPEUTIC APPROACH FOR CYSTIC FIBROSIS
Haggie, P. M.
Tan, J.
Phuan, P.
Finkbeiner, W. E.
Verkman, A. S.
PEDIATRIC PULMONOLOGY, 2015, 50 : 275 - 275
[23] Small-molecule PARP modulators - Current status and future therapeutic potential
Penning, Thomas D.
CURRENT OPINION IN DRUG DISCOVERY & DEVELOPMENT, 2010, 13 (05) : 577 - 586
[24] High throughput screening of a small molecule chemical library reveals novel therapeutic potential drugs in treatment of diabetic retinopathy
Acosta, Gabriella
Monickaraj, Finny
Das, Arup
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2021, 62 (08)
[25] Therapeutic Potential of Thymoquinone and Its Nanoformulations in Pulmonary Injury: A Comprehensive Review
Al-Gabri, Naif A.
Saghir, Sultan A. M.
Al-Hashedi, Sallah A.
El-Far, Ali H.
Khafaga, Asmaa F.
Swelum, Ayman A.
Al-wajeeh, Abdullah S.
Mousa, Shaker A.
Abd El-Hack, Mohamed E.
Naiel, Mohammed A. E.
El-Tarabily, Khaled
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2021, 16 : 5117 - 5131
[26] Transcript Profiling and RNA Interference as Tools To Identify Small Molecule Mechanisms and Therapeutic Potential
Palchaudhuri, Rahul
Hergenrother, Paul J.
ACS CHEMICAL BIOLOGY, 2011, 6 (01) : 21 - 33
[27] Small-Molecule Inhibitor Targeting Protein Kinase D: A Potential Therapeutic Strategy
Lv, Die
Chen, Hongli
Feng, Yun
Cui, Bomiao
Kang, Yingzhu
Zhang, Ping
Luo, Min
Chen, Jiao
FRONTIERS IN ONCOLOGY, 2021, 11
[28] Identification of a novel small molecule chaperon of rhodopsin and its therapeutic potential in retinal degeneration
Chen, Yuanyuan
Chen, Yu
Jastrzebska, Beata
Tang, Hong
Li, Xiaoyu
Siebel, William
Zhang, Jianye
Jin, Hui
Gulati, Sahil
Palczewski, Krzysztof
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
[29] Computational approach to design small molecule inhibitors and identify SarA as a potential therapeutic candidate
Arya, Rekha
Princy, S. Adline
MEDICINAL CHEMISTRY RESEARCH, 2013, 22 (04) : 1856 - 1865
[30] Tapping the therapeutic potential of protein tyrosine phosphatase 4A with small molecule inhibitors
Tasker, Nikhil R.
Rastelli, Ettore J.
Burnett, James C.
Sharlow, Elizabeth R.
Lazo, John S.
Wipf, Peter
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2019, 29 (16) : 2008 - 2015

← 1 2 3 4 5 →