Thymoquinone: A small molecule from nature with high therapeutic potential

被引：33

作者：

Malik, Safiya ^{[1
]}

Singh, Amardeep ^{[1
]}

Negi, Poonam ^{[1
]}

Kapoor, Vijay Kumar ^{[1
]}

机构：

[1] Shoolini Univ, Sch Pharmaceut Sci, Solan 173212, India

来源：

DRUG DISCOVERY TODAY | 2021年 / 26卷 / 11期

关键词：

Thymoquinone; Analogs; Biological activities; Clinical trials; Preclinical studies; Molecular mechanism; Nanotechnology; NF-KAPPA-B; OXIDATIVE STRESS; RHEUMATOID-ARTHRITIS; INDUCED INFLAMMATION; BREAST-CANCER; TNF-ALPHA; EXPRESSION; MODEL; INHIBITION; PROTECTS;

D O I：

10.1016/j.drudis.2021.07.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Thymoquinone (TQ; 2-isopropyl-5-methylbenzo-1, 4-quinone), the main active constituent of Nigella sativa, has been proven to have great therapeutic properties in numerous in vivo and in vitro models. Nevertheless, this molecule is not yet in clinical trials, largely because of its poor bioavailability and hydrophobicity. This review examines the different activities of TQ, as well as various combination therapies, nanotechnologies and clinical trials involving TQ. The TQ nanoparticle formulation shows better bioavailability than free TQ, and it is time for clinical trials of these formulations to realize the potential of TQ as a therapeutic.

引用

页码：2716 / 2725

页数：10

共 50 条

[31] Potential therapeutic medicines for renal fibrosis: Small-molecule compounds and natural products
Xiang, Yu
Yuan, Zhuo
Deng, Qichuan
Xie, Linshen
Yu, Dongke
Shi, Jianyou
BIOORGANIC CHEMISTRY, 2024, 143
[32] Therapeutic potential of an orally effective small molecule inhibitor of plasminogen activator inhibitor for asthma
Liu, Rui-Ming
Eldridge, Stephanie
Watanabe, Nobuo
Deshane, Jessy
Kuo, Hui-Chien
Jiang, Chunsun
Wang, Yong
Liu, Gang
Schwiebert, Lisa
Miyata, Toshio
Thannickal, Victor J.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2016, 310 (04) : 1328 - 1336
[33] Small-molecule chemical probes for the potential therapeutic targets in alcoholic liver diseases
Dogra, Ashish
Li, Feng
LIVER RESEARCH, 2023, 7 (03) : 177 - 188
[34] A small molecule that targets the processivity factor of molluscum contagiosum virus has therapeutic potential
Guan, Hancheng
Nuth, Manunya
Isaacs, Stuart N.
Xiao, Yuhong
Scott, Richard W.
Parker, Michael H.
Strobel, Eric D.
Kulp, John L., III
Bailey, Thomas R.
Reitz, Allen B.
Ricciardi, Robert P.
ANTIVIRAL RESEARCH, 2023, 211
[35] Junctional adhesion molecule 3 is a potential therapeutic target for small cell lung carcinoma
Yamaguchi, Miki
Hirai, Sachie
Idogawa, Masashi
Sumi, Toshiyuki
Uchida, Hiroaki
Fujitani, Naoki
Takahashi, Motoko
Sakuma, Yuji
EXPERIMENTAL CELL RESEARCH, 2023, 426 (02)
[36] Computational approach to design small molecule inhibitors and identify SarA as a potential therapeutic candidate
Rekha Arya
S. Adline Princy
Medicinal Chemistry Research, 2013, 22 : 1856 - 1865
[37] Potential therapeutic application of small molecule with sulfonamide for chondrogenic differentiation and articular cartilage repair
Choi, Eunhyun
Lee, Jiyun
Lee, Seahyoung
Song, Byeong-Wook
Seo, Hyang-Hee
Cha, Min-Ji
Lim, Soyeon
Lee, Chulho
Song, Suk-Won
Han, Gyoonhee
Hwang, Ki-Chul
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2016, 26 (20) : 5098 - 5102
[38] Discovery of Small Molecule Drugs with Therapeutic Potential for Hyperoxalemia, Hyperoxaluria, and Related Kidney Stones
Hassan, Hatim A.
Subramaniam, Marina
Dunne, Sara Fernandez
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2024, 35 (10):
[39] Thymoquinone, as an anticancer molecule: from basic research to clinical investigation
Khan, Md Asaduzzaman
Tania, Mousumi
Fu, Shangyi
Fu, Junjiang
ONCOTARGET, 2017, 8 (31) : 51907 - 51919
[40] MicroRNA as a Potential Therapeutic Molecule in Cancer
Szczepanek, Joanna
Skorupa, Monika
Tretyn, Andrzej
CELLS, 2022, 11 (06)

← 1 2 3 4 5 →