Efficient Pd(ii)-catalyzed regioselective ortho-halogenation of arylcyanamides

被引：3
|
作者：
Boddapati, S. N. Murthy [1 ,2 ]
Tamminana, Ramana [3 ]
Alam, M. Mujahid [4 ]
Gugulothu, Sailaja [1 ]
Varala, Ravi [5 ]
Bollikolla, Hari Babu [1 ]
机构：
[1] Acharya Nagarjuna Univ, Dept Chem, Guntur 522510, AP, India
[2] Sir CR Reddy Coll, Dept Chem, PG Courses, Eluru 534007, AP, India
[3] GITAM, Dept Chem, Bengaluru Campus, Bengaluru 562163, Karnataka, India
[4] King Khalid Univ, Coll Sci, Dept Chem, POB 9004, Abha 61413, Saudi Arabia
[5] Scrips Pharma, Hyderabad, Telangana, India
来源：
NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 37期
关键词：
CATALYZED C-H; CROSS-COUPLING REACTIONS; BOND ACTIVATION; DIRECTING-GROUP; N-FLUOROBENZENESULFONIMIDE; OXIDATIVE CYCLOADDITION; MEDICINAL CHEMISTRY; ORTHO-ALKENYLATION; AROMATIC NITRILES; ORTHO-BROMINATION;
D O I：
10.1039/d1nj01998h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Regioselective ortho-halogenation of arylcyanamides using a Pd(ii) catalyst has been established under mild reaction conditions. Either electron-donating or electron-withdrawing groups readily carried out the reaction and produced final products in moderate to good yields. Based on the experimental work, we have confirmed that this method does not undergo a free radical mechanism. Furthermore, we have also attempted this method for practical utility purposes.
引用
收藏
页码：17176 / 17182
页数：7
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