Efficient Pd(ii)-catalyzed regioselective ortho-halogenation of arylcyanamides

被引：3

作者：

Boddapati, S. N. Murthy ^{[1
,2
]}

Tamminana, Ramana ^{[3
]}

Alam, M. Mujahid ^{[4
]}

Gugulothu, Sailaja ^{[1
]}

Varala, Ravi ^{[5
]}

Bollikolla, Hari Babu ^{[1
]}

机构：

[1] Acharya Nagarjuna Univ, Dept Chem, Guntur 522510, AP, India

[2] Sir CR Reddy Coll, Dept Chem, PG Courses, Eluru 534007, AP, India

[3] GITAM, Dept Chem, Bengaluru Campus, Bengaluru 562163, Karnataka, India

[4] King Khalid Univ, Coll Sci, Dept Chem, POB 9004, Abha 61413, Saudi Arabia

[5] Scrips Pharma, Hyderabad, Telangana, India

来源：

NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 37期

关键词：

CATALYZED C-H; CROSS-COUPLING REACTIONS; BOND ACTIVATION; DIRECTING-GROUP; N-FLUOROBENZENESULFONIMIDE; OXIDATIVE CYCLOADDITION; MEDICINAL CHEMISTRY; ORTHO-ALKENYLATION; AROMATIC NITRILES; ORTHO-BROMINATION;

D O I：

10.1039/d1nj01998h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Regioselective ortho-halogenation of arylcyanamides using a Pd(ii) catalyst has been established under mild reaction conditions. Either electron-donating or electron-withdrawing groups readily carried out the reaction and produced final products in moderate to good yields. Based on the experimental work, we have confirmed that this method does not undergo a free radical mechanism. Furthermore, we have also attempted this method for practical utility purposes.

引用

页码：17176 / 17182

页数：7

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