Iron(III)-Catalyzed Highly Regioselective Halogenation of 8-Amidoquinolines in Water

被引：9
|
作者：
Long, Yang [1 ]
Pan, Lei [1 ]
Zhou, Xiangge [1 ]
机构：
[1] Sichuan Univ, Coll Chem, Chengdu 610064, Sichuan, Peoples R China
来源：
MOLECULES | 2019年 / 24卷 / 03期
基金：
中国国家自然科学基金;
关键词：
8-amidoquinoline; iron; catalysis; water; QUINOLINE N-OXIDES; RHODIUM(III)-CATALYZED C-C; METAL-FREE; 8-AMINOQUINOLINE AMIDES; C5-H BROMINATION; SODIUM-HALIDES; H-HALOGENATION; C-8; POSITION; COPPER; ARYLATION;
D O I：
10.3390/molecules24030535
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A simple protocol of iron(III)-catalyzed halogenation of 8-amidoquinolines in water under mild conditions was developed, affording the 5-halogenlated products in good to excellent yields up to 98%. The reaction mechanism most likely involves a single-electron transfer (SET) process.
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页数：14
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