Efficient solid-phase synthesis of 1,3,4-trisubstituted β-thiolactams

被引：17
|
作者：
Méndez, L [1 ]
Delpiccolo, CML [1 ]
Mata, EG [1 ]
机构：
[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis,UNR, RA-2000 Rosario, Santa Fe, Argentina
来源：
SYNLETT | 2005年 / 10期
关键词：
solid-phase synthesis; beta-thiolactams; Lawesson's reagent; beta-lactams; combinatorial chemistry;
D O I：
10.1055/s-2005-869855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient solid-phase synthesis of a series of 1,3,4-trisubstituted beta-thiolactams is described. The key reaction, a direct thionation of polymer-supported beta-lactams, was carried out using the Lawesson's reagent to give beta-thiolactams in good overall yields.
引用
收藏
页码：1563 / 1566
页数：4
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