Efficient solid-phase synthesis of 1,3,4-trisubstituted β-thiolactams

被引：17
|
作者：
Méndez, L [1 ]
Delpiccolo, CML [1 ]
Mata, EG [1 ]
机构：
[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis,UNR, RA-2000 Rosario, Santa Fe, Argentina
来源：
SYNLETT | 2005年 / 10期
关键词：
solid-phase synthesis; beta-thiolactams; Lawesson's reagent; beta-lactams; combinatorial chemistry;
D O I：
10.1055/s-2005-869855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient solid-phase synthesis of a series of 1,3,4-trisubstituted beta-thiolactams is described. The key reaction, a direct thionation of polymer-supported beta-lactams, was carried out using the Lawesson's reagent to give beta-thiolactams in good overall yields.
引用
收藏
页码：1563 / 1566
页数：4
相关论文
共 50 条
  • [11] Synthesis of 1,3,4-trisubstituted 2,5-dioxopyrrolidines and their swirling ability
    Varshavskaya, NF
    Galatina, AI
    Derkach, LG
    Kondrateva, RV
    Novikova, NS
    Kilimenchuk, ED
    ZHURNAL ORGANICHESKOI KHIMII, 1997, 33 (07): : 1075 - 1077
  • [12] 3 1,3,4-TRISUBSTITUTED BETA-LACTAM ANTIBIOTICS
    CHIARONI, A
    RICHE, C
    ANAYA, J
    GATEAUOLESKER, A
    GERO, SD
    HERNANDO, JIM
    ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1994, 50 : 1474 - 1480
  • [13] Synthesis of 1,3,4-trisubstituted Pyrazoles from baylis-hillman adducts
    Kim, Hoo Sook
    Kim, Sung Hwan
    Kim, Jae Nyoung
    BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2007, 28 (10): : 1841 - 1843
  • [14] Microwave-Enhanced Efficient Regioselective Synthesis of 1,3,4-Trisubstituted 2-Mercaptoimidazoles on a Soluble Support
    Yellol, Gorakh S.
    Chou, Cheng-Ting
    Chang, Wang-Jin
    Maiti, Barnali
    Sun, Chung-Ming
    ADVANCED SYNTHESIS & CATALYSIS, 2012, 354 (01) : 187 - 196
  • [15] Solid-phase synthesis of substituted 1,3,4-thiadiazoles
    Kilburn, JP
    Lau, J
    Jones, RCF
    TETRAHEDRON LETTERS, 2003, 44 (42) : 7825 - 7828
  • [16] Solid-phase synthesis of trisubstituted guanidines
    Drewry, DH
    Gerritz, SW
    Linn, JA
    TETRAHEDRON LETTERS, 1997, 38 (19) : 3377 - 3380
  • [17] Regioselective synthesis of 1,3,4-trisubstituted cobalticinium salts: Dehydroxymethylation of tetrasubstituted cyclopentadiene ligands
    Connor, Joseph O.
    Qin, Pengjin
    Melaimi, Mohand-Ameziane
    Moore, Curtis
    Rheingold, Arnold
    Holland, Ryan
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 254
  • [18] Synthesis of novel 1,3,4-trisubstituted pyrazoles as anti-inflammatory and analgesic agents
    Ragab, Fatma A.
    Gawad, Nagwa M. Abdel
    Georgey, Hanan H.
    Said, Mona F.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2013, 63 : 645 - 654
  • [19] Synthesis of novel 1,3,4-trisubstituted pyrazole derivatives and their evaluation as antitumor and antiangiogenic agents
    Abadi, AH
    Eissa, AAH
    Hassan, GS
    CHEMICAL & PHARMACEUTICAL BULLETIN, 2003, 51 (07) : 838 - 844
  • [20] 1,3,4-TRISUBSTITUTED PIPERIDINE DERIVATIVES FROM MANNICH BASES
    PLATI, JT
    SCHMIDT, RA
    WENNER, W
    JOURNAL OF ORGANIC CHEMISTRY, 1949, 14 (05): : 873 - 878
12345