Efficient solid-phase synthesis of 1,3,4-trisubstituted β-thiolactams

被引：17
|
作者：
Méndez, L [1 ]
Delpiccolo, CML [1 ]
Mata, EG [1 ]
机构：
[1] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, CONICET, Inst Quim Organ Sintesis,UNR, RA-2000 Rosario, Santa Fe, Argentina
来源：
SYNLETT | 2005年 / 10期
关键词：
solid-phase synthesis; beta-thiolactams; Lawesson's reagent; beta-lactams; combinatorial chemistry;
D O I：
10.1055/s-2005-869855
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient solid-phase synthesis of a series of 1,3,4-trisubstituted beta-thiolactams is described. The key reaction, a direct thionation of polymer-supported beta-lactams, was carried out using the Lawesson's reagent to give beta-thiolactams in good overall yields.
引用
收藏
页码：1563 / 1566
页数：4
相关论文
共 50 条
  • [21] Solid-phase synthesis of 1,3,4-thiadiazolium-2-aminides
    Kappel, Joseph C.
    Yokum, T. Scott
    Barany, George
    PEPTIDE REVOLUTION: GENOMICS, PROTEOMICS & THERAPEUTICS, 2004, : 839 - 840
  • [22] Solid-phase synthesis of 1,3,4-thiadiazolium-2-aminides
    Kappel, JC
    Yokum, TS
    Barany, G
    BIOPOLYMERS, 2003, 71 (03) : 364 - 364
  • [23] Traceless Solid-Phase Synthesis of Trisubstituted Quinazolines
    Fueloepova, Veronika
    Cziesla, Lauren
    Fleming, Megan
    Lu, Yiwei
    Voelker, Adrienne
    Krchnak, Viktor
    ACS COMBINATORIAL SCIENCE, 2015, 17 (08) : 470 - 473
  • [24] Solid-phase synthesis of trisubstituted benzamides.
    Grimstrup, M
    Zaragoza, F
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U209 - U209
  • [25] Parallel solid-phase synthesis of trisubstituted triazinobenzimidazolediones
    Klein, G
    Acharya, AN
    Ostresh, JM
    Houghten, RA
    JOURNAL OF COMBINATORIAL CHEMISTRY, 2002, 4 (04): : 345 - 351
  • [26] Synthesis, in silico experiments and biological evaluation of 1,3,4-trisubstituted pyrazole derivatives as antimalarial agents
    Bekhit, Adnan A.
    Saudi, Manal N.
    Hassan, Ahmed M. M.
    Fahmy, Salwa M.
    Ibrahim, Tamer M.
    Ghareeb, Doaa
    El-Seidy, Aya M.
    Nasralla, Sherry N.
    Bekhit, Alaa El-Din A.
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 163 : 353 - 366
  • [27] Visible-Light-Driven Synthesis of 1,3,4-Trisubstituted Pyrroles from Aryl Azides
    Liu, Yang
    Parodi, Adriano
    Battaglioli, Simone
    Monari, Magda
    Protti, Stefano
    Bandini, Marco
    ORGANIC LETTERS, 2019, 21 (19) : 7782 - 7786
  • [28] Synthesis and biological evaluation of 1,3,4-trisubstituted pyrazole analogues as anti-mycobacterial agents
    Alegaon, Shankar G.
    Hirpara, Mita B.
    Alagawadi, K. R.
    Jalalpure, S. S.
    Rasal, V. P.
    Salve, Preeti S.
    Kumbar, V. M.
    MEDICINAL CHEMISTRY RESEARCH, 2017, 26 (06) : 1127 - 1138
  • [29] 1,3,4-TRISUBSTITUTED PYRROLIDINONES AS SCAFFOLDS FOR CONSTRUCTION OF PEPTIDOMIMETIC CHOLECYSTOKININ ANTAGONISTS
    FLYNN, DL
    VILLAMIL, CI
    BECKER, DP
    GULLIKSON, GW
    MOUMMI, C
    YANG, DC
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1992, 2 (10) : 1251 - 1256
  • [30] Synthesis and biological evaluation of 1,3,4-trisubstituted pyrazole analogues as anti-mycobacterial agents
    Shankar G. Alegaon
    Mita B. Hirpara
    K. R. Alagawadi
    S. S. Jalalpure
    V. P. Rasal
    Preeti S. Salve
    V. M. Kumbar
    Medicinal Chemistry Research, 2017, 26 : 1127 - 1138
12345