C(2)-Functionalization of pyrimidin-4(3H)-one derivatives in the synthesis of its biologically active derivatives

被引：4

作者：

Novakov, I. A. ^{[1
]}

Navrotskii, M. B. ^{[1
]}

Zakharova, E. K. ^{[1
]}

Brunilina, L. L. ^{[1
]}

机构：

[1] Volgograd State Tech Univ, 28 Prosp Lenina, Volgograd 400131, Russia

来源：

RUSSIAN CHEMICAL BULLETIN | 2015年 / 64卷 / 11期

关键词：

isocytosine; uracil; 2-thiouracil; REVERSE-TRANSCRIPTASE INHIBITORS; H2-RECEPTOR HISTAMINE-ANTAGONISTS; IMMUNODEFICIENCY-VIRUS TYPE-1; SELECTIVE ANTI-HIV-1 AGENTS; ANTI-HIV ACTIVITY; ANTITUMOR-ACTIVITY; MKC-442; ANALOGS; PYRIMIDINE-DERIVATIVES; ANTIVIRAL ACTIVITY; 3,4-DIHYDRO-2-ALKOXY-6-BENZYL-4-OXOPYRIMIDINES DABOS;

D O I：

10.1007/s11172-015-1190-1

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Different approaches to the formation of biologically active isocytosine, uracil, and 2-thiouracil derivatives based on the C(2)-regioselective functionalization of pyrimidin-4(3H)-one framework were considered.

引用

页码：2545 / 2561

页数：17

共 50 条

[21] Efficient Synthesis,Crystal Structure and Antibacterial Activity of Two Novel Thieno[2,3-d]pyrimidin-4(3H)-one Derivatives
LI Rong-Kun
YANG Quan-Li
HUANG Nian-Yu
CHEN Hong
LIU Ming-Guo
结构化学, 2015, 34 (05) : 673 - 680
[22] 2-methoxy-3-methyl-6-[(triphenylphosphoranylidene)amino]pyrimidin-4(3H)-one and 3-methyl-2-methylthio-6-[(triphenylphosphoranylidene)amino]pyrimidin-4(3H)-one
Low, JN
Ferguson, G
Cobo, J
Nogueras, M
Sanchez, A
Marchal, A
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS, 1998, 54 : 1355 - 1357
[23] Efficient Synthesis, Crystal Structure and Antibacterial Activity of Two Novel Thieno[2,3-d]pyrimidin-4(3H)-one Derivatives
Li Rong-Kun
Yang Quan-Li
Huang Nian-Yu
Chen Hong
Liu Ming-Guo
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY, 2015, 34 (05) : 673 - 680
[24] Priority directions in the design of biologically active compounds based on 2-aminopyrimidin-4(3H)-one and its derivatives
Erkin, Andrei V.
Krutikov, Viktor I.
Garabadzhiu, Alexander V.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2021, 57 (02) : 103 - 121
[25] Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido [4,3-d]pyrimidin-4(3H)-one and pyrido [4,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors
Banerjee, Abhisek
Pawar, Mahesh Y.
Patil, Sandip
Yadav, Pravin S.
Kadam, Pradip A.
Kattige, Vidya G.
Deshpande, Durga S.
Pednekar, Pallavi V.
Pisat, Monali K.
Gharat, Laxmikant A.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2014, 24 (20) : 4838 - 4844
[26] Priority directions in the design of biologically active compounds based on 2-aminopyrimidin-4(3H)-one and its derivatives
Andrei V. Erkin
Viktor I. Krutikov
Alexander V. Garabadzhiu
Chemistry of Heterocyclic Compounds, 2021, 57 : 103 - 121
[27] Physicochemical properties and antimicrobial activity of new spirocyclic thieno[2,3-d]pyrimidin-4(3H)-one derivatives
de Candia, Modesto
Altamura, Claudia
Denora, Nunzio
Cellamare, Saverio
Nuzzolese, Manuel
De Vito, Danila
Voskressensky, Leonid G.
Varlamov, Alexey V.
Altomare, Cosimo D.
CHEMISTRY OF HETEROCYCLIC COMPOUNDS, 2017, 53 (03) : 357 - 363
[28] A Green and Facile Synthesis of 6-Methyl-2-(alkylthio)pyrimidin-4(3H)-one
Kotaiah, S.
Ramadevi, B.
Naidu, A.
Dubey, P. K.
ASIAN JOURNAL OF CHEMISTRY, 2013, 25 (17) : 9869 - 9871
[29] Physicochemical properties and antimicrobial activity of new spirocyclic thieno[2,3-d]pyrimidin-4(3H)-one derivatives
Modesto de Candia
Claudia Altamura
Nunzio Denora
Saverio Cellamare
Manuel Nuzzolese
Danila De Vito
Leonid G. Voskressensky
Alexey V. Varlamov
Cosimo D. Altomare
Chemistry of Heterocyclic Compounds, 2017, 53 : 357 - 363
[30] Synthesis of Substituted Pyrimidin-4(1H)-one (Uracil) Derivatives and Some of Their Reactions
Barmaki, Mohammad
JOURNAL OF THE CHEMICAL SOCIETY OF PAKISTAN, 2011, 33 (06): : 893 - 899

← 1 2 3 4 5 →