Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

被引：6
|
作者：
Duran-Ortiz, Silvana [1 ,2 ,3 ]
Noboa, Vanessa [4 ]
Kopchick, John J. [1 ,3 ,5 ]
机构：
[1] Edison Biotechnol Inst, Athens, OH USA
[2] Coll Arts & Sci, Dept Biol Sci, Athens, OH USA
[3] Mol & Cellular Biol Program, Athens, OH USA
[4] Univ San Francisco Quito, Sch Med, Quito, Ecuador
[5] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA
来源：
GROWTH HORMONE & IGF RESEARCH | 2020年 / 51卷
关键词：
Growth hormone receptor; IGF-I; Liver; Adipose tissue; Brain; Macrophages; Bone; Intestine; Heart; Tissue-specific; IGF-I; ADIPOSE-TISSUE; GENE; GLUCOSE; DELETION; REVEALS; LESSONS; AXIS;
D O I：
10.1016/j.ghir.2019.12.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.
引用
收藏
页码：1 / 5
页数：5
相关论文
共 50 条
  • [1] Deconstructing the Growth Hormone Receptor (GHR): Physical and Metabolic Phenotypes of Tissue-Specific GHR Gene-Disrupted Mice
    Young, Jonathan A.
    List, Edward O.
    Kopchick, John J.
    GROWTH HORMONE IN HEALTH AND DISEASE, 2016, 138 : 27 - 39
  • [2] Tissue-specific GHR knockout mice: metabolic phenotypes
    Sun, Liou Y.
    Bartke, Andrzej
    FRONTIERS IN ENDOCRINOLOGY, 2015, 5
  • [3] Tissue-Specific GHR Knockout Mice: An Updated Review
    Nagarajan, Akash
    Srivastava, Hemant
    Jablonsky, Joseph
    Sun, Liou Y.
    FRONTIERS IN ENDOCRINOLOGY, 2020, 11
  • [4] New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
    List, Edward O.
    Berryman, Darlene E.
    Jensen, Elizabeth A.
    Kulkarni, Prateek
    McKenna, Savannah
    Kopchick, John J.
    ARCHIVES OF ENDOCRINOLOGY METABOLISM, 2019, 63 (06): : 557 - 567
  • [5] Tissue-specific developmental regulation of insulin-like growth factor (IGF-I) and growth hormone receptor (GHR) mRNA in the rat.
    Shoba, L
    An, MR
    Lowe, WL
    JOURNAL OF INVESTIGATIVE MEDICINE, 1996, 44 (07) : A372 - A372
  • [6] Growth hormone receptor/binding protein (GHR/BP) knockout mice: A 3-year update
    List, EO
    Coschigano, KT
    Kopchick, JJ
    MOLECULAR GENETICS AND METABOLISM, 2001, 73 (01) : 1 - 10
  • [7] Abnormal liver lipids in mice with a targeted disruption of the growth hormone receptor binding protein (GHR/BP) gene
    Ng, VL
    Coschigano, K
    Kopchick, JJ
    Bezerra, JA
    Howles, P
    Yeh, YY
    Tso, P
    GASTROENTEROLOGY, 1999, 116 (04) : A630 - A630
  • [8] Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice
    Jia Tong
    Simon G. Lillico
    Ming Jun Bi
    Tong Qing
    Xiao Fang Liu
    YuanYuan Wang
    Min Zheng
    Meili Wang
    Yun Ping Dai
    C. Bruce A. Whitelaw
    Ning Li
    Transgenic Research, 2011, 20 : 933 - 938
  • [9] Tissue-specific and expression of porcine growth hormone gene in BAC transgenic mice
    Tong, Jia
    Lillico, Simon G.
    Bi, Ming Jun
    Qing, Tong
    Liu, Xiao Fang
    Wang, YuanYuan
    Zheng, Min
    Wang, Meili
    Dai, Yun Ping
    Whitelaw, C. Bruce A.
    Li, Ning
    TRANSGENIC RESEARCH, 2011, 20 (04) : 933 - 938
  • [10] Tissue-specific molecular heterogeneity of human growth hormone-releasing hormone receptor protein
    Fujinaka, Y
    Yokogoshi, Y
    Zhang, CY
    Okura, T
    Kitagawa, K
    Saito, S
    FEBS LETTERS, 1996, 394 (01) : 1 - 4
12345