Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

被引：6

作者：

Duran-Ortiz, Silvana ^{[1
,2
,3
]}

Noboa, Vanessa ^{[4
]}

Kopchick, John J. ^{[1
,3
,5
]}

机构：

[1] Edison Biotechnol Inst, Athens, OH USA

[2] Coll Arts & Sci, Dept Biol Sci, Athens, OH USA

[3] Mol & Cellular Biol Program, Athens, OH USA

[4] Univ San Francisco Quito, Sch Med, Quito, Ecuador

[5] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA

来源：

GROWTH HORMONE & IGF RESEARCH | 2020年 / 51卷

关键词：

Growth hormone receptor; IGF-I; Liver; Adipose tissue; Brain; Macrophages; Bone; Intestine; Heart; Tissue-specific; IGF-I; ADIPOSE-TISSUE; GENE; GLUCOSE; DELETION; REVEALS; LESSONS; AXIS;

D O I：

10.1016/j.ghir.2019.12.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.

引用

页码：1 / 5

页数：5

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