Tissue-specific disruption of the growth hormone receptor (GHR) in mice: An update

被引:6
|
作者
Duran-Ortiz, Silvana [1 ,2 ,3 ]
Noboa, Vanessa [4 ]
Kopchick, John J. [1 ,3 ,5 ]
机构
[1] Edison Biotechnol Inst, Athens, OH USA
[2] Coll Arts & Sci, Dept Biol Sci, Athens, OH USA
[3] Mol & Cellular Biol Program, Athens, OH USA
[4] Univ San Francisco Quito, Sch Med, Quito, Ecuador
[5] Ohio Univ, Heritage Coll Osteopath Med, Dept Biomed Sci, Athens, OH 45701 USA
关键词
Growth hormone receptor; IGF-I; Liver; Adipose tissue; Brain; Macrophages; Bone; Intestine; Heart; Tissue-specific; IGF-I; ADIPOSE-TISSUE; GENE; GLUCOSE; DELETION; REVEALS; LESSONS; AXIS;
D O I
10.1016/j.ghir.2019.12.004
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Growth hormone receptor (GHR) is expressed in many cells/tissues in the body. To investigate the specific metabolic effects of GH action in distinct tissues, several tissue-specific GHR gene disrupted or knockout (KO) mouse lines have been generated. Previously, we have described the effects of GHRKO in several known insulin sensitive tissues, namely liver, muscle and adipose tissue. In this review, we further explore and summarize the main findings of recently published GHRKO results in liver, adipocytes, intestine, bone, brain and heart.
引用
收藏
页码:1 / 5
页数:5
相关论文
共 50 条
  • [41] TISSUE-SPECIFIC SORTING OF THE HUMAN LDL RECEPTOR IN POLARIZED EPITHELIA OF TRANSGENIC MICE
    PATHAK, RK
    YOKODE, M
    HAMMER, RE
    HOFMANN, SL
    BROWN, MS
    GOLDSTEIN, JL
    ANDERSON, RGW
    JOURNAL OF CELL BIOLOGY, 1990, 111 (02): : 347 - 359
  • [42] Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression
    Zengel, J. R.
    Wang, Y. X.
    Wseo, J.
    Hamilton, J. N.
    Wu, B.
    Raie, M.
    Holbrook, C.
    Su, S.
    Pillay, S.
    Puschnik, A. S.
    Nagamine, C.
    Ferrara, K.
    Blau, H. M.
    Carette, J. E.
    HUMAN GENE THERAPY, 2022, 33 (23-24) : A27 - A27
  • [43] Hardwiring tissue-specific AAV transduction in mice through engineered receptor expression
    Zengel, James
    Wang, Yu Xin
    Seo, Jai Woong
    Ning, Ke
    Hamilton, James. N. N.
    Wu, Bo
    Raie, Marina
    Holbrook, Colin
    Su, Shiqi
    Clements, Derek. R. R.
    Pillay, Sirika
    Puschnik, Andreas. S. S.
    Winslow, Monte. M. M.
    Idoyaga, Juliana
    Nagamine, Claude. M. M.
    Sun, Yang
    Mahajan, Vinit. B. B.
    Ferrara, Katherine. W. W.
    Blau, Helen. M. M.
    Carette, Jan. E. E.
    NATURE METHODS, 2023, 20 (07) : 1070 - +
  • [44] Disruption of Growth Hormone Receptor in Adipocytes Improves Insulin Sensitivity and Lifespan in Mice
    List, Edward O.
    Berryman, Darlene E.
    Slyby, Julie
    Duran-Ortiz, Silvana
    Funk, Kevin
    Bisset, Elise S.
    Howlett, Susan E.
    Kopchick, John J.
    ENDOCRINOLOGY, 2022, 163 (10)
  • [45] Growth hormone-receptor disruption in mice reduces osteoarthritis and chondrocyte hypertrophy
    Liu, Huanhuan
    Davis, Trent
    Duran-Ortiz, Silvana
    Martino, Tom
    Erdely, Austin
    Profio, Shane
    Osipov, Benjamin
    Loots, Gabriela G.
    Berryman, Darlene E.
    O'Connor, Patrick M.
    Kopchick, John J.
    Zhu, Shouan
    GEROSCIENCE, 2024, : 4895 - 4908
  • [46] Association of Growth Traits with SSCP Polymorphisms at the Growth Hormone Receptor (GHR) and Growth Hormone Releasing Hormone Receptor (GHRHR) Genes in the Baluchi Sheep
    Valeh, Mehdi Vafaye
    Tahmoorespour, Mojtaba
    Ansari, Mazyar
    Nassiry, Mohammad Reza
    Karimi, Davood
    Taheri, Amir
    JOURNAL OF ANIMAL AND VETERINARY ADVANCES, 2009, 8 (06): : 1063 - 1069
  • [47] Effects of the Truncated Human Growth Hormone Receptor (GHR) on Downstream Signaling
    Nakonechnaya, Alona O.
    Pagano, Christopher
    Goodyer, Cynthia Gates
    ENDOCRINE REVIEWS, 2014, 35 (03)
  • [48] A conformationally sensitive GHR [growth hormone (GH) receptor] antibody: Impact on GH signaling and GHR proteolysis
    Jiang, J
    Wang, XD
    He, K
    Li, X
    Chen, CM
    Sayeski, PP
    Waters, MJ
    Frank, SJ
    MOLECULAR ENDOCRINOLOGY, 2004, 18 (12) : 2981 - 2996
  • [49] Growth Hormone Receptor (GHR) 6Ω Pseudoexon Activation: A Novel Cause of Severe Growth Hormone Insensitivity
    Cottrell, Emily
    Maharaj, Avinaash
    Williams, Jack
    Chatterjee, Sumana
    Cirillo, Grazia
    del Giudice, Emanuele Miraglia
    Festa, Adalgisa
    Palumbo, Stefania
    Capalbo, Donatella
    Salerno, Mariacarolina
    Pignata, Claudio
    Savage, Martin O.
    Schilbach, Katharina
    Bidlingmaier, Martin
    Hwa, Vivian
    Metherell, Louise A.
    Grandone, Anna
    Storr, Helen L.
    JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2022, 107 (01): : E401 - E416
  • [50] Regulation of the Human Growth Hormone Receptor (GHR) Expression in Obesity.
    Erman, A.
    Goodyer, C. G.
    ENDOCRINE REVIEWS, 2010, 31 (03)