The Application of Multicomponent Ugi and Passerini Reactions for the One-Pot Synthesis of Pyrrolones and Butenolides

被引：19
|
作者：
Nechaev, Anton A. [1 ]
Peshkov, Anatoly A. [1 ]
Peshkov, Vsevolod A. [2 ]
Van der Eycken, Erik V. [1 ]
机构：
[1] Univ Leuven, Dept Chem, LOMAC, KU Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium
[2] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Dushu Lake Campus, Suzhou 215123, Peoples R China
来源：
SYNTHESIS-STUTTGART | 2016年 / 48卷 / 14期
基金：
比利时弗兰德研究基金会;
关键词：
Ugi reaction; Passerini reaction; propiolic acid; ethyl glyoxylate; pyrrolone; butenolide; BETA-LACTAMS; COMBINATORIAL SYNTHESIS; FACILE SYNTHESIS; ISOCYANIDES; TRANSFORMATIONS; HETEROCYCLES; ANALOGS; ACCESS; ROUTE;
D O I：
10.1055/s-0035-1561422
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new protocol for the one-pot synthesis of pyrrolones and butenolides involving an isocyanide-based multicomponent reaction (Ugi or Passerini) followed by a triethylamine-promoted cycloisomerization is described.
引用
收藏
页码：2280 / 2286
页数：7
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