Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

被引：25
|
作者：
Kanai, Kazutaka [1 ]
Nagata, Sho [1 ]
Hatta, Takuya [1 ]
Sugiura, Yuichi [1 ]
Sato, Kazuaki [1 ]
Yamashita, Yohei [1 ]
Kimura, Yuya [1 ]
Itoh, Naoyuki [1 ]
机构：
[1] Kitasato Univ, Sch Vet Med, Dept Small Anim Internal Med 1, Towada, Aomori 0348628, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 08期
关键词：
anti-inflammatory effect; endotoxin-induced uveitis; luteolin; prednisolone; therapeutic effect; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; KAPPA-B; INFLAMMATION; LIPOPOLYSACCHARIDE; PHARMACOKINETICS; MACROPHAGES; ACTIVATION; INHIBITOR; INJECTION;
D O I：
10.1292/jvms.16-0196
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 mu g) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-alpha, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.
引用
收藏
页码：1381 / 1384
页数：4
相关论文
共 50 条
  • [31] Cloricromene protects against endotoxin-induced uveitis in Lewis rats.
    Bucolo, C
    Cuzzocrea, S
    Mazzon, E
    Maltese, A
    Cro, M
    Caputi, AP
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2001, 42 (04) : S919 - S919
  • [32] The effects of naringin and naringenin on endotoxin-induced uveitis in rats
    Shiratori, K
    Ohgami, K
    Ilieva, I
    Jin, XH
    Yoshida, K
    Kase, S
    Ohno, S
    JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, 2005, 21 (04) : 298 - 304
  • [33] Effects of Gold Nanoparticles on Endotoxin-Induced Uveitis in Rats
    Pereira, David Valter
    Petronilho, Fabricia
    Silveira Benevides Pereira, Hilda Regina
    Vuolo, Francieli
    Mina, Francieli
    Possato, Jonathan Correa
    Vitto, Marcelo Fontana
    de Souza, Daniela Roxo
    da Silva, Luciano
    da Silva Paula, Marcos Marques
    de Souza, Claudio Teodoro
    Dal-Pizzol, Felipe
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2012, 53 (13) : 8036 - 8041
  • [34] The Effects of Betamethasone Derivatives on Endotoxin-induced Uveitis in Rats
    Tsuji, F.
    Sawa, K.
    Kato, M.
    Mibu, H.
    Experimental Eye Research, 64 (01):
  • [35] The effects of betamethasone derivatives on endotoxin-induced uveitis in rats
    Tsuji, F
    Sawa, K
    Kato, M
    Mibu, R
    Shirasawa, E
    EXPERIMENTAL EYE RESEARCH, 1997, 64 (01) : 31 - 36
  • [36] ANOMALOUS EFFECTS OF ANTI-INFLAMMATORY CORTICOSTEROIDS IN ENDOTOXIN-INDUCED OCULAR INFLAMMATION
    WILLIAMS, RN
    PATERSON, CA
    EUROPEAN JOURNAL OF PHARMACOLOGY, 1984, 106 (01) : 113 - 119
  • [37] Anti-Inflammatory Effect of Dexamethasone Controlled Released From Anterior Suprachoroidal Polyurethane Implants on Endotoxin-Induced Uveitis in Rats
    Saliba, Juliana Barbosa
    Vieira, Lorena
    Fernandes-Cunha, Gabriella Maria
    Da Silva, Gisele Rodrigues
    Fialho, Silvia Ligorio
    Silva-Cunha, Armando
    Bousquet, Elodie
    Naud, Marie-Christine
    Ayres, Eliane
    Orefice, Rodrigo Lambert
    Tekaya, Meriem
    Kowalczuk, Laura
    Zhao, Min
    Behar-Cohen, Francine
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (04) : 1671 - 1679
  • [38] The Anti-Inflammatory Effect of Ripasudil (K-115), a Rho Kinase (ROCK) Inhibitor, on Endotoxin-Induced Uveitis in Rats
    Uchida, Takatoshi
    Honjo, Megumi
    Yamagishi, Reiko
    Aihara, Makoto
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (12) : 5584 - 5593
  • [39] Anti-Inflammatory Effect of Dehydroxymethylepoxyquinomicin, a Nuclear factor-κB Inhibitor, on Endotoxin-Induced Uveitis in Rats In vivo and In vitro
    Ando, Yoshimasa
    Keino, Hiroshi
    Kudo, Akihiko
    Hirakata, Akito
    Okada, Annabelle A.
    Umezawa, Kazuo
    OCULAR IMMUNOLOGY AND INFLAMMATION, 2020, 28 (02) : 240 - 248
  • [40] Annexin A1 Mimetic Peptide and Piperlongumine: Anti-Inflammatory Profiles in Endotoxin-Induced Uveitis
    Girol, Ana Paula
    Zanon, Caroline de Freitas
    Caruso, Icaro Putinhon
    Costa, Sara de Souza
    Souza, Helena Ribeiro
    Cornelio, Marinonio Lopes
    Oliani, Sonia Maria
    CELLS, 2021, 10 (11)
12345