Therapeutic anti-inflammatory effects of luteolin on endotoxin-induced uveitis in Lewis rats

被引：25
|
作者：
Kanai, Kazutaka [1 ]
Nagata, Sho [1 ]
Hatta, Takuya [1 ]
Sugiura, Yuichi [1 ]
Sato, Kazuaki [1 ]
Yamashita, Yohei [1 ]
Kimura, Yuya [1 ]
Itoh, Naoyuki [1 ]
机构：
[1] Kitasato Univ, Sch Vet Med, Dept Small Anim Internal Med 1, Towada, Aomori 0348628, Japan
来源：
JOURNAL OF VETERINARY MEDICAL SCIENCE | 2016年 / 78卷 / 08期
关键词：
anti-inflammatory effect; endotoxin-induced uveitis; luteolin; prednisolone; therapeutic effect; TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE; KAPPA-B; INFLAMMATION; LIPOPOLYSACCHARIDE; PHARMACOKINETICS; MACROPHAGES; ACTIVATION; INHIBITOR; INJECTION;
D O I：
10.1292/jvms.16-0196
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The present study aimed to investigate the therapeutic efficacy of post-inflammatory treatment with luteolin on endotoxin-induced uveitis (EIU) in rats. Intraperitoneal injection of 10 mg/kg luteolin or 1 mg/kg prednisolone (Pred) at 4 hr post-lipopolysaccharide (LPS) injection (200 mu g) was associated at 24 hr post-LPS injection with decreased clinical severity scores, number of inflammatory cells, protein levels and levels of tumor necrosis factor (TNF)-alpha, nitric oxide (NO) and prostaglandin (PG) E2 in the aqueous humor (AqH) and degrees of histological ocular tissue injury. The anti-inflammatory potency of luteolin was comparable to that of Pred. Luteolin exhibited robust efficacy in the treatment of EIU in rats, indicating its potential clinical utility in treating uveitis.
引用
收藏
页码：1381 / 1384
页数：4
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