A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles

被引：65

作者：

Lin, Xufeng ^{[1
]}

Mao, Zhenjun ^{[1
]}

Dai, Xixiang ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 23期

基金：

中国国家自然科学基金;

关键词：

1,3-DICARBONYL COMPOUNDS; PROPARGYLIC ALCOHOLS; SUBSTITUTED PYRROLES; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; COUPLING REACTION; DOMINO REACTION; ATOM ECONOMY; AMINES; CYCLOADDITION;

D O I：

10.1039/c1cc11363a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.

引用

页码：6620 / 6622

页数：3

共 50 条

[41] One-pot synthesis of pyrimidine linked naphthoquinone-fused pyrroles by iodine-mediated multicomponent reactions
Panday, Anoop Kumar
Ali, Danish
Choudhury, Lokman H.
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2020, 18 (26) : 4997 - 5007
[42] A one-pot synthesis of polysubstituted imidazol[1,2-a]pyridines
Kiselyov, AS
[J]. TETRAHEDRON LETTERS, 2006, 47 (17) : 2941 - 2944
[43] One-pot multicomponent reactions
Lombardo, M
Trombini, C
[J]. SEMINARS IN ORGANIC SYNTHESIS, 1998, : 7 - 32
[44] One-pot synthesis of polysubstituted 3-acylpyrroles by cooperative catalysis
Cui, Hai-Lei
Tanaka, Fujie
[J]. ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 12 (31) : 5822 - 5826
[45] Catalyst-free one-pot three-component rapid synthesis of polysubstituted pyrroles by liquid-assisted grinding
Jiang, Ling
Yan, Si-Yu
Dong, Jing-Wen
Ye, Li-Dan
Cheng, Yue
Chu, Xiao-He
[J]. JOURNAL OF HETEROCYCLIC CHEMISTRY, 2022, 59 (09) : 1561 - 1572
[46] Efficient one-pot synthesis of biologically active polysubstituted aromatic amines
Menche, Dirk
Arikan, Fatih
Li, Jun
Rudolph, Sven
Sasse, Florenz
[J]. BIOORGANIC & MEDICINAL CHEMISTRY, 2007, 15 (23) : 7311 - 7317
[47] One-pot synthesis of polysubstituted pyridine derivatives using ketene dithioacetals
Hagimori, Masayori
Mizuyama, Naoko
Hisadome, Yukari
Nagaoka, Junko
Ueda, Kazuo
Tominaga, Yoshinori
[J]. TETRAHEDRON, 2007, 63 (11) : 2511 - 2518
[48] Palladium-Based Nanocatalyst for One-Pot Synthesis of Polysubstituted Quinolines
Chen, Benjamin Wei Jie
Chng, Leng Leng
Yang, Jun
Wei, Yifeng
Yang, Jinhua
Ying, Jackie Y.
[J]. CHEMCATCHEM, 2013, 5 (01) : 277 - 283
[49] Multistep One-Pot Synthesis of Enantioenriched Polysubstituted Cyclopenta[b]indoles
Xu, Biao
Guo, Zhi-Lei
Jin, Wan-Yan
Wang, Zhi-Ping
Peng, Yun-Gui
Guo, Qi-Xiang
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2012, 51 (04) : 1059 - 1062
[50] Bronsted-Acid-Catalyzed Multicomponent One-Pot Reaction: Efficient Synthesis of Polysubstituted 1,2-Dihydropyridines
Xie, Yi-Bi
Ye, Si-Pei
Chen, Wei-Feng
Hu, Yu-Lin
Li, De-Jiang
Wang, Long
[J]. ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2017, 6 (06) : 746 - 750

← 1 2 3 4 5 →