Efficient one-pot synthesis of biologically active polysubstituted aromatic amines

被引：12

作者：

Menche, Dirk ^{[1
]}

Arikan, Fatih ^{[1
]}

Li, Jun ^{[1
]}

Rudolph, Sven ^{[1
]}

Sasse, Florenz ^{[2
]}

机构：

[1] Infekt Forsch GmbH, Helmholtz Zentrum, Med Chem, D-38124 Braunschweig, Germany

[2] Infekt Forsch GmbH, Helmholtz Zentrum, Chem Biol, D-38124 Braunschweig, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 23期

关键词：

aromatic amines; reductive amination; diversity-oriented synthesis; one-pot synthesis; cytotoxicity;

D O I：

10.1016/j.bmc.2007.08.048

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

An efficient and modular one-pot synthesis of polysubstituted aromatic amines by a mild reductive amination procedure is described and the biological potential of these nitrogen-centered compounds is demonstrated by growth inhibition of murine connective tissue cells and microscopy-based morphological studies. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：7311 / 7317

页数：7

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