A straightforward one-pot multicomponent synthesis of polysubstituted pyrroles

被引：65

作者：

Lin, Xufeng ^{[1
]}

Mao, Zhenjun ^{[1
]}

Dai, Xixiang ^{[1
]}

Lu, Ping ^{[1
]}

Wang, Yanguang ^{[1
]}

机构：

[1] Zhejiang Univ, Dept Chem, Hangzhou 310027, Zhejiang, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 23期

基金：

中国国家自然科学基金;

关键词：

1,3-DICARBONYL COMPOUNDS; PROPARGYLIC ALCOHOLS; SUBSTITUTED PYRROLES; EFFICIENT SYNTHESIS; ORGANIC-SYNTHESIS; COUPLING REACTION; DOMINO REACTION; ATOM ECONOMY; AMINES; CYCLOADDITION;

D O I：

10.1039/c1cc11363a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polysubstituted pyrroles were efficiently synthesized in moderate yields by a one-pot multicomponent reaction starting from primary amines, ethyl glyoxalate and 2-bromoacetophenones in the presence of pyridine in refluxing acetonitrile. This methodology was utilized to synthesize a highly substituted benz[g]indole.

引用

页码：6620 / 6622

页数：3

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