Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

被引：1301

作者：

Kebir, Hania

Kreymborg, Katharina

Ifergan, Igal

Dodelet-Devillers, Aurore

Cayrol, Romain

Bernard, Monique

Giuliani, Fabrizio

Arbour, Nathalie

Becher, Burkhard

Prat, Alexandre

机构：

[1] Univ Montreal, Notre Dame Hosp, Ctr Hosp, Ctr Study Brain Dis,Neuroimmunol Unit, Montreal, PQ H2L 4M1, Canada

[2] Univ Zurich, Dept Neurol, Div Neuroimmunol, CH-8057 Zurich, Switzerland

[3] Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2G3, Canada

来源：

NATURE MEDICINE | 2007年 / 13卷 / 10期

基金：

加拿大健康研究院;

关键词：

D O I：

10.1038/nm1651

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL- 17 and IL- 22 receptors on blood- brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL- 17 and IL- 22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4(+) lymphocyte recruitment.

引用

页码：1173 / 1175

页数：3

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