Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation

被引：1301
|
作者：
Kebir, Hania
Kreymborg, Katharina
Ifergan, Igal
Dodelet-Devillers, Aurore
Cayrol, Romain
Bernard, Monique
Giuliani, Fabrizio
Arbour, Nathalie
Becher, Burkhard
Prat, Alexandre
机构：
[1] Univ Montreal, Notre Dame Hosp, Ctr Hosp, Ctr Study Brain Dis,Neuroimmunol Unit, Montreal, PQ H2L 4M1, Canada
[2] Univ Zurich, Dept Neurol, Div Neuroimmunol, CH-8057 Zurich, Switzerland
[3] Univ Alberta, Dept Med, Div Neurol, Edmonton, AB T6G 2G3, Canada
来源：
NATURE MEDICINE | 2007年 / 13卷 / 10期
基金：
加拿大健康研究院;
关键词：
D O I：
10.1038/nm1651
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
T(H)17 lymphocytes appear to be essential in the pathogenesis of numerous inflammatory diseases. We demonstrate here the expression of IL- 17 and IL- 22 receptors on blood- brain barrier endothelial cells (BBB-ECs) in multiple sclerosis lesions, and show that IL- 17 and IL- 22 disrupt BBB tight junctions in vitro and in vivo. Furthermore, T(H)17 lymphocytes transmigrate efficiently across BBB-ECs, highly express granzyme B, kill human neurons and promote central nervous system inflammation through CD4(+) lymphocyte recruitment.
引用
收藏
页码：1173 / 1175
页数：3
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