Utilization of nanotechnology to surmount the blood-brain barrier in disorders of the central nervous system

被引：1
|
作者：
Luo, Qian [1 ,2 ,3 ]
Yang, Jiaying [2 ,3 ]
Yang, Mei [2 ,3 ]
Wang, Yingtong [4 ]
Liu, Yiran [1 ]
Liu, Jixuan [2 ,3 ]
Kalvakolanu, Dhan, V [5 ]
Cong, Xianling [1 ]
Zhang, Jinnan [1 ]
Zhang, Ling [2 ,3 ]
Guo, Baofeng [1 ]
Duo, Yanhong [6 ]
机构：
[1] Jilin Univ, China Japan Union Hosp, Dept Plast Surg, Changchun 130033, Peoples R China
[2] Jilin Univ, Coll Basic Med Sci, Key Lab Pathobiol, Minist Educ, Changchun 130021, Peoples R China
[3] Jilin Univ, Coll Basic Med Sci, Dept Biomed Sci, Changchun 130021, Peoples R China
[4] Jilin Univ, Hosp Stomatol, Undergraduate Ctr, Changchun 130021, Peoples R China
[5] Univ Maryland, Greenebaum NCI Comprehens Canc Ctr, Sch Med, Dept Microbiol & Immunol, Baltimore, MD USA
[6] Harvard Univ, John A Paulson Sch Engn & Appl Sci, Cambridge, MA 02138 USA
来源：
MATERIALS TODAY BIO | 2025年 / 31卷
基金：
中国国家自然科学基金;
关键词：
Nanoscale delivery platforms; Nano-sized particles; Disorders of the central nervous system; Cerebrovascular barrier; ENHANCED DRUG-DELIVERY; SILICA NANOPARTICLES; PARKINSONS-DISEASE; IN-VITRO; GOLD NANOPARTICLES; LOADED LIPOSOMES; TUMOR BARRIER; GENE DELIVERY; GLIOBLASTOMA; THERAPY;
D O I：
10.1016/j.mtbio.2025.101457
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Central nervous system (CNS) diseases are a major cause of disability and death worldwide. Due to the bloodbrain barrier (BBB), drug delivery for CNS diseases is extremely challenging. Nano-delivery systems can overcome the limitations of BBB to deliver drugs to the CNS, improve the ability of drugs to target the brain and provide potential therapeutic methods for CNS diseases. At the same time, the choice of different drug delivery methods (bypassing BBB or crossing BBB) can further optimize the therapeutic effect of the nano-drug delivery system. This article reviews the different methods of nano-delivery systems to overcome the way BBB enters the brain. Different kinds of nanoparticles to overcome BBB were discussed in depth.
引用
收藏
页数：32
相关论文
共 50 条
  • [1] Glucocorticoid signalling and resistance at the blood-brain barrier in central nervous system disorders
    Kleinschnitz, Christoph
    Blecharz, Kinga
    Kahles, Timo
    Schwarz, Tobias
    Kraft, Peter
    Goebel, Kerstin
    Meuth, Sven G.
    Burek, Malgorzata
    Tha, Serge
    Scheffer, David
    Thum, Thomas
    Stoll, Guido
    Foerster, Carola
    VASCULAR PHARMACOLOGY, 2012, 56 (5-6) : 355 - 355
  • [2] Neurological disorders and therapeutics targeted to surmount the blood-brain barrier
    Kanwar, Jagat R.
    Sriramoju, Bhasker
    Kanwar, Rupinder K.
    INTERNATIONAL JOURNAL OF NANOMEDICINE, 2012, 7 : 3259 - 3278
  • [3] Role of the Blood-Brain Barrier in the Nutrition of the Central Nervous System
    Campos-Bedolla, Patricia
    Walter, Fruzsina R.
    Veszelka, Szilvia
    Deli, Maria A.
    ARCHIVES OF MEDICAL RESEARCH, 2014, 45 (08) : 610 - 638
  • [4] Primary Central Nervous System Lymphoma and the Blood-Brain Barrier
    Doolittle, Nancy D.
    Fu, Rochelle
    Ambady, Prakash
    Neuwelt, Edward A.
    BLOOD, 2016, 128 (22)
  • [5] Immunologic privilege in the central nervous system and the blood-brain barrier
    Muldoon, Leslie L.
    Alvarez, Jorge I.
    Begley, David J.
    Boado, Ruben J.
    del Zoppo, Gregory J.
    Doolittle, Nancy D.
    Engelhardt, Britta
    Hallenbeck, John M.
    Lonser, Russell R.
    Ohlfest, John R.
    Prat, Alexandre
    Scarpa, Maurizio
    Smeyne, Richard J.
    Drewes, Lester R.
    Neuwelt, Edward A.
    JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (01): : 13 - 21
  • [6] The blood-brain barrier and drug delivery in the central nervous system
    Loch-Neckel, Gecioni
    Koepp, Janice
    REVISTA DE NEUROLOGIA, 2010, 51 (03) : 165 - 174
  • [7] Structure, Function, and Regulation of the Blood-Brain Barrier Tight Junction in Central Nervous System Disorders
    Lochhead, Jeffrey J.
    Yang, Junzhi
    Ronaldson, Patrick T.
    Davis, Thomas P.
    FRONTIERS IN PHYSIOLOGY, 2020, 11
  • [8] Crossing the blood-brain barrier to central nervous system gene therapy
    Lewis, MES
    CLINICAL GENETICS, 1999, 56 (01) : 10 - 10
  • [9] Nanoparticles and Blood-Brain Barrier: The Key to Central Nervous System Diseases
    Dominguez, Alazne
    Suarez-Merino, Blanca
    Goni-de-Cerio, Felipe
    JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, 2014, 14 (01) : 766 - 779
  • [10] RELATION OF THE GROUND SUBSTANCE OF THE CENTRAL NERVOUS SYSTEM TO THE BLOOD-BRAIN BARRIER
    HESS, A
    NATURE, 1955, 175 (4452) : 387 - 388
12345