Dynamic and complex Mycobacterium tuberculosis microevolution unrevealed by standard genotyping

被引：4
|
作者：
Perez-Lago, Laura [1 ,2 ]
Herranz, Marta [1 ,2 ]
Bouza, Emilio [1 ,2 ]
Garcia de Viedma, Dario [1 ,2 ]
机构：
[1] Univ Gregorio Maranon, Gen Hosp, Serv Microbiol & Enfermedades Infecciosas, Madrid 28007, Spain
[2] Inst Invest Sanitaria Gregorio Maranon, Madrid, Spain
来源：
TUBERCULOSIS | 2012年 / 92卷 / 03期
关键词：
Mycobacterium tuberculosis; Microevolution; Transmission cluster; Clonal variants; POLYMORPHISM; TRANSMISSION; STRAINS;
D O I：
10.1016/j.tube.2012.01.003
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We performed an in-depth analysis of a large Mycobacterium tuberculosis cluster involving nine isolates with identical or highly similar RFLP types. The strain involved in this transmission cluster microevolved and accumulated up to five differential IS6110 transposition events, several of them not revealed by standard genotyping approaches. Some of these events probably generated extended deletions. In two cases of tuberculosis within the cluster, we observed the simultaneous presence of both the reference and microevolved variants. A longitudinal genotypical survey of M. tuberculosis in a real clinical evolutionary scenario can reveal dynamic and complex microevolution events. (C) 2012 Elsevier Ltd. All rights reserved.
引用
收藏
页码：232 / 235
页数：4
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