Genotyping of Mycobacterium tuberculosis: application in epidemiologic studies

被引：29

作者：

Kato-Maeda, Midori ^{[1
]}

Metcalfe, John Z. ^{[1
]}

Flores, Laura ^{[1
]}

机构：

[1] Univ Calif San Francisco, San Francisco Gen Hosp, Francis J Curry Natl TB Ctr, Div Pulm & Crit Care Med, San Francisco, CA 94110 USA

来源：

FUTURE MICROBIOLOGY | 2011年 / 6卷 / 02期

关键词：

IS6110RFLP; MIRU-VNTR; molecular epidemiology; public health; spoligotyping; TB; whole-genome sequencing; FRAGMENT-LENGTH-POLYMORPHISM; DIRECT REPEAT LOCUS; VARIABLE-NUMBER; MOLECULAR EPIDEMIOLOGY; RECENT TRANSMISSION; GENETIC DIVERSITY; BEIJING GENOTYPE; SAN-FRANCISCO; PULMONARY TUBERCULOSIS; POPULATION-STRUCTURE;

D O I：

10.2217/FMB.10.165

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Genotyping is used to track specific isolates of Mycobacterium tuberculosis in a community. It has been successfully used in epidemiologic research (termed 'molecular epidemiology') to study the transmission dynamics of TB. In this article, we review the genetic markers used in molecular epidemiologic studies including the use of whole-genome sequencing technology. We also review the public health application of molecular epidemiologic tools.

引用

页码：203 / 216

页数：14

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