Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents

被引：14
|
作者：
Everett, Dean B. [1 ]
Weiss, Helen A. [1 ]
Changalucha, John [2 ]
Anemona, Alessandra [1 ]
Chirwa, Tobias [2 ]
Ross, David A. [1 ]
Watson-Jones, Deborah [1 ]
Parry, John V. [3 ]
Hayes, Richard [1 ]
Mabey, David C. [1 ]
机构：
[1] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
[2] Natl Inst Med Res, Mwanza, Tanzania
[3] Ctr Infect, Hlth Protect Agcy, London, England
来源：
TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2007年 / 12卷 / 11期
基金：
英国医学研究理事会;
关键词：
HIV tests; Africa; specificity; false positives;
D O I：
10.1111/j.1365-3156.2007.01933.x
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
OBJECTIVE To determine the specificity of the Abbott Murex HIV antigen/antibody combination enzyme immunoassay (EIA) for the diagnosis of HIV infection in Tanzania. METHODS A cross-sectional survey of 7333 Tanzanian adolescents and young adults was carried out. Sera testing positive by the Murex assay were further evaluated using a battery of other EIA which detect either antibody to HIV-1 or p24 antigen, and by PCR using pol primers. RESULTS Of the 674 sera testing positive by the Murex assay, only 53 (7.9%) were confirmed. The specificity of the Murex assay was 91.5%. CONCLUSIONS Serological tests for HIV may perform differently in different populations. New diagnostic tests should not be introduced into populations in which they have not been evaluated.
引用
收藏
页码：1323 / 1326
页数：4
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