Low specificity of the Murex fourth-generation HIV enzyme immunoassay in Tanzanian adolescents

被引：14
|
作者：
Everett, Dean B. [1 ]
Weiss, Helen A. [1 ]
Changalucha, John [2 ]
Anemona, Alessandra [1 ]
Chirwa, Tobias [2 ]
Ross, David A. [1 ]
Watson-Jones, Deborah [1 ]
Parry, John V. [3 ]
Hayes, Richard [1 ]
Mabey, David C. [1 ]
机构：
[1] Univ London London Sch Hyg & Trop Med, London WC1E 7HT, England
[2] Natl Inst Med Res, Mwanza, Tanzania
[3] Ctr Infect, Hlth Protect Agcy, London, England
来源：
TROPICAL MEDICINE & INTERNATIONAL HEALTH | 2007年 / 12卷 / 11期
基金：
英国医学研究理事会;
关键词：
HIV tests; Africa; specificity; false positives;
D O I：
10.1111/j.1365-3156.2007.01933.x
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
OBJECTIVE To determine the specificity of the Abbott Murex HIV antigen/antibody combination enzyme immunoassay (EIA) for the diagnosis of HIV infection in Tanzania. METHODS A cross-sectional survey of 7333 Tanzanian adolescents and young adults was carried out. Sera testing positive by the Murex assay were further evaluated using a battery of other EIA which detect either antibody to HIV-1 or p24 antigen, and by PCR using pol primers. RESULTS Of the 674 sera testing positive by the Murex assay, only 53 (7.9%) were confirmed. The specificity of the Murex assay was 91.5%. CONCLUSIONS Serological tests for HIV may perform differently in different populations. New diagnostic tests should not be introduced into populations in which they have not been evaluated.
引用
收藏
页码：1323 / 1326
页数：4
相关论文
共 50 条
  • [21] Development and Evaluation of a Modified Fourth-Generation Human Immunodeficiency Virus Enzyme Immunoassay for Cross-Sectional Incidence Estimation in Clade B Populations
    Kirkpatrick, Allison R.
    Patel, Eshan U.
    Celum, Connie L.
    Moore, Richard D.
    Blankson, Joel N.
    Mehta, Shruti H.
    Kirk, Gregory D.
    Margolick, Joseph B.
    Quinn, Thomas C.
    Eshleman, Susan H.
    Laeyendecker, Oliver
    AIDS RESEARCH AND HUMAN RETROVIRUSES, 2016, 32 (08) : 756 - 762
  • [22] Low rates of HIV p24 antigen detection using a fourth-generation point-of-care test
    Fox, J.
    Dunn, H.
    O'Shea, S.
    HIV MEDICINE, 2010, 11 : 38 - 38
  • [23] Evaluation of Enhanced Low Dose Rate Sensitivity in Fourth-Generation SiGe HBTs
    Fleetwood, Zachary E.
    Cardoso, Adilson S.
    Song, Ickhyun
    Wilcox, Edward
    Lourenco, Nelson E.
    Phillips, Stanley D.
    Arora, Rajan
    Paki-Amouzou, Pauline
    Cressler, John D.
    IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 2014, 61 (06) : 2915 - 2922
  • [24] Cost-effectiveness of a Fourth-Generation Combination Immunoassay for Human Immunodeficiency Virus (HIV) Antibody and p24 Antigen for the Detection of HIV Infections in the United States
    Cragin, Lael
    Pan, Feng
    Peng, Siyang
    Zenilnnan, Jonathan M.
    Green, Julia
    Doucet, Cynthia
    Chalfin, Donald B.
    de Lissovoy, Greg
    HIV CLINICAL TRIALS, 2012, 13 (01): : 11 - 22
  • [25] Performance evaluation of a new fourth-generation HIV combination antigen-antibody assay
    Muehlbacher, A.
    Schennach, H.
    van Helden, J.
    Hebell, T.
    Pantaleo, G.
    Buergisser, P.
    Cellerai, C.
    Permpikul, P.
    Rodriguez, M. I.
    Eiras, A.
    Alborino, F.
    Cunningham, P.
    Axelsson, M.
    Andersson, S.
    Wetlitzky, O.
    Kaiser, C.
    Moeller, P.
    de Sousa, G.
    MEDICAL MICROBIOLOGY AND IMMUNOLOGY, 2013, 202 (01) : 77 - 86
  • [26] Evaluation of third- and fourth-generation point-of-care tests for the detection of HIV
    Khanom, A.
    Hurday, S.
    Holmes, M.
    Chaytor, S.
    Evans, A.
    Garcia, A.
    Johnson, M.
    Haque, T.
    Webster, D.
    HIV MEDICINE, 2013, 14 : 45 - 45
  • [27] Clinical Application Evaluation of a Fourth-Generation HIV Antigen Antibody Combination Screening Assay
    Han, Hui
    Huang, Yanhua
    Dong, Qian
    Huang, Yunxiu
    Lu, Jianqiang
    Wang, Weijia
    Chen, Kang
    CLINICAL LABORATORY, 2019, 65 (10) : 1853 - 1858
  • [28] Accuracy of a Fourth-Generation Continuous Glucose Monitoring System in Children and Adolescents with Type 1 Diabetes
    Slover, Robert H.
    Tryggestad, Jeanie B.
    DiMeglio, Linda A.
    Fox, Larry A.
    Bode, Bruce W.
    Bailey, Timothy S.
    Brazg, Ronald
    Christiansen, Mark P.
    Sherr, Jennifer L.
    Tsalikian, Eva
    Kaiserman, Kevin B.
    Sullivan, Ashley
    Huang, Suiying
    Shin, John
    Lee, Scott W.
    Kaufman, Francine R.
    DIABETES TECHNOLOGY & THERAPEUTICS, 2018, 20 (09) : 576 - 584
  • [29] Evaluation of Four Qualitative Third-Generation HIV Antibody Assays and the Fourth-Generation Abbott HIV Ag/Ab Combo Test
    Wians, Frank H.
    Moore, Holly A.
    Briscoe, Donna
    Anderson, Kathy M.
    Hicks, Pamela S.
    Smith, Debbie L.
    Clark, Tammy A.
    Preton, Maggie M.
    Gammons, Beckie
    Ray, Cynthia S.
    Bond, Christine
    West, Joshua T.
    LABMEDICINE, 2011, 42 (09): : 523 - 535
  • [30] False-positive fourth-generation HIV test result in a woman with Plasmodium malariae malaria
    Ainoda, Yusuke
    Komaki-Yasuda, Kanako
    Kano, Shigeyuki
    Hirai, Yuji
    TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE, 2023, 117 (02) : 147 - 148
12345