Two new sesquiterpenoid glycosides from the leaves of Lycium barbarum

被引：16

作者：

Wang, Yan ^{[1
,3
]}

Zhao, Bo ^{[2
]}

Ma, Hai-Rong ^{[1
]}

Aisa, Haji Akber ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Plant Resources & Chem Arid Reg, Urumqi 830011, Peoples R China

[2] Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Key Lab Xinjiang Indigenous Med Plants Resource U, Urumqi 830011, Peoples R China

[3] Univ Chinese Acad Sci, Beijing 100039, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2016年 / 18卷 / 09期

关键词：

Solanaceae; Lycium barbarum; sesquiterpenoid glycosides; antiproliferative activities; POLYSACCHARIDES; PEPTIDES;

D O I：

10.1080/10286020.2016.1171756

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new sesquiterpenoid glycosides, lyciumionosides A-B (1-2), together with four known compounds (3-6), were isolated from the leaves of Lycium barbarum. Their structures were mainly established on the basis of MS, 1D and 2D NMR spectroscopic techniques. The antiproliferative activities of compounds 1-5 were evaluated. Compound 1 showed highest inhibitory activity against A549 cells with IC50 value of 32.6 +/- 2.6 mu M, compound 3 showed highest inhibitory activity against PC-3 cells with IC50 value of 36.0 +/- 2.9 mu M, and compound 5 exhibited highest inhibitory activity against HeLa cells with IC50 value of 32.3 +/- 4.2 mu M.

引用

页码：871 / 877

页数：7

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