Expression of a novel Nef epitope on the surface of HIV type 1-infected cells

被引：11
|
作者：
Yamada, T [1 ]
Iwamoto, A [1 ]
机构：
[1] Univ Tokyo, Inst Med Sci, Dept Infect Dis, Minato Ku, Tokyo 1088639, Japan
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 1999年 / 15卷 / 11期
关键词：
D O I：
10.1089/088922299310511
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We compared antibody responses to various structural and accessory gene products of HIV-1 between longterm nonprogressors and patients who have progressed to AIDS, On the basis of our results, we performed epitope mapping of the Nef protein and identified a novel epitope. This novel epitope of the Nef protein was found to be exposed on the surface of HIV-1-infected cells, The antibody response against it correlated with CD4(+) cell counts among HIV-1-infected patients (r = 0.457, p < 0.001). Although further research is necessary, we suspect that antibody response against the epitope may be protective against disease progression.
引用
收藏
页码：1001 / 1009
页数：9
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