Diversity of HIV Type 1 Envelope (V3-V5) Sequence in HIV Type 1-Infected Indian Children

被引：0

作者：

Prakash, Somi Sankaran ^{[1
]}

Kalra, Rajesh ^{[1
]}

Lodha, Rakesh ^{[2
]}

Kabra, Sushil K. ^{[2
]}

Luthra, Kalpana ^{[1
]}

机构：

[1] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India

[2] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 05期

关键词：

V4; DETERMINANTS; GP120;

D O I：

10.1089/aid.2011.0206

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.

引用

页码：505 / 509

页数：5

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