Diversity of HIV Type 1 Envelope (V3-V5) Sequence in HIV Type 1-Infected Indian Children

被引：0
|
作者：
Prakash, Somi Sankaran [1 ]
Kalra, Rajesh [1 ]
Lodha, Rakesh [2 ]
Kabra, Sushil K. [2 ]
Luthra, Kalpana [1 ]
机构：
[1] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India
[2] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 05期
关键词：
V4; DETERMINANTS; GP120;
D O I：
10.1089/aid.2011.0206
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.
引用
收藏
页码：505 / 509
页数：5
相关论文
共 50 条
  • [31] Management of herpes simplex virus type 2 infection in HIV type 1-infected persons
    Strick, Lara B.
    Wald, Anna
    Celum, Connie
    [J]. CLINICAL INFECTIOUS DISEASES, 2006, 43 (03) : 347 - 356
  • [32] HIV Type 1 Integrase Polymorphisms in Treatment-Naive and Treatment-Experienced HIV Type 1-Infected Patients in Thailand Where HIV Type 1 Subtype A/E Predominates
    Phuphuakrat, Angsana
    Pasomsub, Ekawat
    Kiertiburanakul, Sasisopin
    Chantratita, Wasun
    Sungkanuparph, Somnuek
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2012, 28 (08) : 937 - 943
  • [33] Loci Polymorphisms of the APOBEC3G Gene in HIV Type 1-Infected Brazilians
    Bizinoto, Maria Clara
    Leal, Elcio
    Diaz, Ricardo Sobhie
    Janini, Luiz Mario
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2011, 27 (02) : 137 - 141
  • [34] LACK OF HIV-1 V3 REGION SEQUENCE DIVERSITY IN 2 HEMOPHILIAC PATIENTS INFECTED WITH A PUTATIVE BIOLOGIC CLONE OF HIV-1
    CICHUTEK, K
    NORLEY, S
    LINDE, R
    KREUZ, W
    GAHR, M
    LOWER, J
    VONWANGENHEIM, G
    KURTH, R
    [J]. AIDS, 1991, 5 (10) : 1185 - 1187
  • [35] Diversity of antibody binding to V3 peptides representing consensus sequences of HIV type 1 genotypes A to E: An approach for HIV type 1 serological subtyping
    Barin, F
    Lahbabi, Y
    Buzelay, L
    Lejeune, B
    BaillouBeaufils, A
    Denis, F
    Mathiot, C
    MBoup, S
    Vithayasai, V
    Dietrich, U
    Goudeau, A
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1996, 12 (13) : 1279 - 1289
  • [36] IN-VIVO EFFECTS OF INTERLEUKIN-3 IN HIV TYPE 1-INFECTED PATIENTS WITH CYTOPENIA
    SCADDEN, DT
    LEVINE, JD
    BRESNAHAN, J
    GERE, J
    MCGRATH, J
    WANG, ZY
    RESTA, DJ
    YOUNG, D
    HAMMER, SM
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 (06) : 731 - 740
  • [37] HIV-1 INTRAPATIENT SEQUENCE DIVERSITY IN THE IMMUNOGENIC V3 REGION
    KORBER, B
    WOLINSKY, S
    HAYNES, B
    KUNSTMAN, K
    LEVY, R
    FURTADO, M
    OTTO, P
    MYERS, G
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1992, 8 (08) : 1461 - 1465
  • [38] Evidence of B cell clonal expansion in HIV type 1-infected patients
    Chong, Y
    Ikematsu, H
    Ariyama, I
    Chijiwa, K
    Li, W
    Yamaji, K
    Kashiwagi, S
    Hayashi, J
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2001, 17 (16) : 1507 - 1515
  • [39] IN-VIVO SEQUENCE CHANGES OF HIV-1 ENVELOPE V2 AND V3 LOOPS
    SHIODA, T
    NAGAI, Y
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 : S111 - S111
  • [40] HIV type 1 protease inhibitors enhance bone marrow progenitor cell activity in normal subjects and in HIV type 1-infected patients
    Isgrò, A
    Aiuti, A
    Mezzaroma, I
    Ruco, L
    Pinti, M
    Cossarizza, A
    Aiuti, F
    [J]. AIDS RESEARCH AND HUMAN RETROVIRUSES, 2005, 21 (01) : 51 - 57
12345