Diversity of HIV Type 1 Envelope (V3-V5) Sequence in HIV Type 1-Infected Indian Children

被引：0
|
作者：
Prakash, Somi Sankaran [1 ]
Kalra, Rajesh [1 ]
Lodha, Rakesh [2 ]
Kabra, Sushil K. [2 ]
Luthra, Kalpana [1 ]
机构：
[1] All India Inst Med Sci, Dept Biochem, New Delhi 110029, India
[2] All India Inst Med Sci, Dept Pediat, New Delhi 110029, India
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2012年 / 28卷 / 05期
关键词：
V4; DETERMINANTS; GP120;
D O I：
10.1089/aid.2011.0206
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
We assessed the viral envelope (V3-V5 region) sequence diversity from 13 HIV-1-infected Indian children from north India. All of the 13 children were found to be infected with subtype C viruses. One of the viral sequences exhibited usage of the CXCR4 coreceptor predicted by Web PSSM and Geno2pheno tools. This virus also had a longer V3 sequence with 37 amino acids, a GRGQ motif, and a methionine residue before it (AIIMS_307). A unique finding was the complete deletion of the V4 region of another virus (AIIMS_363). High sequence diversity was observed in the envelope of the HIV-1-infected Indian children.
引用
收藏
页码：505 / 509
页数：5
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