Expression of a novel Nef epitope on the surface of HIV type 1-infected cells

被引：11

作者：

Yamada, T ^{[1
]}

Iwamoto, A ^{[1
]}

机构：

[1] Univ Tokyo, Inst Med Sci, Dept Infect Dis, Minato Ku, Tokyo 1088639, Japan

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1999年 / 15卷 / 11期

关键词：

D O I：

10.1089/088922299310511

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We compared antibody responses to various structural and accessory gene products of HIV-1 between longterm nonprogressors and patients who have progressed to AIDS, On the basis of our results, we performed epitope mapping of the Nef protein and identified a novel epitope. This novel epitope of the Nef protein was found to be exposed on the surface of HIV-1-infected cells, The antibody response against it correlated with CD4(+) cell counts among HIV-1-infected patients (r = 0.457, p < 0.001). Although further research is necessary, we suspect that antibody response against the epitope may be protective against disease progression.

引用

页码：1001 / 1009

页数：9

共 50 条

[41] Increased frequency of CD27- (naive) B cells and their phenotypic alteration in HIV type 1-infected patients
Chong, Y
Ikematsu, H
Yamamoto, M
Murata, M
Yamaji, K
Nishimura, M
Nabeshima, S
Kashiwagi, S
Hayashi, J
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2004, 20 (06) : 621 - 629
[42] Changes in the HIV Type 1 Envelope Gene from Non-Subtype B HIV Type 1-Infected Children in Kenya
Lwembe, Raphael
Lihana, Raphael W.
Ochieng, Washingtone
Panikulam, Annie
Mongoina, Charles O.
Palakudy, Tresa
de Koning, Heleen
Ishizaki, Azumi
Kageyama, Seiji
Musoke, Rachel
Owens, Mary
Songok, Elijah M.
Okoth, Frederick A.
Ichimura, Hiroshi
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2009, 25 (02) : 141 - 147
[43] Assessment of type 1 and type 2 cytokines in HIV type 1-infected individuals: Impact of highly active antiretroviral therapy
Imami, N
Antonopoulos, C
Hardy, GAD
Gazzard, B
Gotch, FM
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1999, 15 (17) : 1499 - 1508
[44] Nef modulation of HIV type 1 gene expression and cytopathicity in tissues of HIV transgenic mice
Dickie, P
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2000, 16 (08) : 777 - 790
[45] Monocytes in HIV type 1-infected individuals lose expression of costimulatory B7 molecules and acquire cytotoxic activity
Dudhane, A
Conti, B
Orlikowsky, T
Wang, ZQ
Mangla, N
Gupta, A
Wormser, GP
Hoffmann, MK
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1996, 12 (10) : 885 - 892
[46] HIV-1 NEF-SPECIFIC CTL CONTROL HIV EPITOPE VARIANTS
AUTRAN, B
HAAS, G
PLIKAT, U
DUDOIT, Y
BONDUELLE, O
KATLAMA, C
MAIER, B
MEYERHANS, A
IHLENFELDT, HG
JUNG, G
DEBRE, P
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1995, 11 : S150 - S150
[47] DNA immunization with HIV early genes in HIV type 1-infected patients on highly active antiretroviral therapy
Hejdeman, B
Boström, AC
Matsuda, R
Calarota, S
Lenkei, R
Fredriksson, EL
Sandström, E
Bratt, G
Wahren, B
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2004, 20 (08) : 860 - 870
[48] Short Communication Natural Killer Cells and Expression of KIR Receptors in Chronic HIV Type 1-Infected Patients after Different Strategies of Structured Therapy Interruption
Mestre, Gabriel
Garcia, Felipe
Martinez, Esteban
Milinkovic, Ana
Lopez, Anna
Leon, Agathe
Mora, Borja
Argelich, Roger
Lozano, Jose Manuel
Pena, Jose
Gatell, Jose M.
Plana, Montserrat
AIDS RESEARCH AND HUMAN RETROVIRUSES, 2008, 24 (12) : 1485 - 1495
[49] Acquired deficiency of functional C1-esterase inhibitor in HIV type 1-infected patients
Gerencer, M
Burek, V
Barrett, NP
AIDS RESEARCH AND HUMAN RETROVIRUSES, 1997, 13 (10) : 813 - 814
[50] CD38 expression in CD8+ T cells predicts virological failure in HIV type 1-infected children receiving antiretroviral therapy
Resino, S
Bellón, JM
Gurbindo, MD
Muñoz-Fernández, MA
CLINICAL INFECTIOUS DISEASES, 2004, 38 (03) : 412 - 417

← 1 2 3 4 5 →