Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

被引：134
|
作者：
Kirschning, Andreas [1 ]
Hahn, Frank [1 ]
机构：
[1] Leibniz Univ Hannover, Inst Organ Chem & Biomol Wirkstoffzentrum BMWZ, D-30167 Hannover, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 17期
关键词：
metabolic engineering; mutasynthesis; natural products; semisynthesis; total synthesis; ANTITUMOR AGENT ANSAMITOCIN; COMBINATORIAL BIOSYNTHESIS; GLYCOPEPTIDE ANTIBIOTICS; SUBSTRATE-SPECIFICITY; GENE-CLUSTER; MUTASYNTHESIS; DERIVATIVES; HSP90; SEMISYNTHESIS; CRYPTOPHYCINS;
D O I：
10.1002/anie.201107386
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
引用
收藏
页码：4012 / 4022
页数：11
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