The total syntheses of phorboxazoles - New classics in natural product synthesis

被引：37
|
作者：
Haustedt, LO [1 ]
Hartung, IV [1 ]
Hofftmann, HMR [1 ]
机构：
[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 24期
关键词：
antitumor agents; macrolides; phorboxazoles; synthesis design; total synthesis;
D O I：
10.1002/anie.200301643
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The marine sponge metabolites phorboxazoles A (see structural formula) and B were the targets of several clever total syntheses, whose special features are described in this Highlight. Now that the synthetic entry to these compounds has been cleared, their cytostatic activity can be studied thoroughly in vitro and in vivo.
引用
收藏
页码：2711 / 2716
页数：6
相关论文
共 50 条
  • [1] Toward the total synthesis of the phorboxazoles.
    Paterson, I
    Luckhurst, CA
    Arnott, EA
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2001, 221 : U199 - U199
  • [2] Progress toward the total synthesis of the phorboxazoles
    Boyer, SJ
    Brzezinski, LJ
    Carroll, DC
    McElhone, KE
    Leahy, JW
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1997, 214 : 272 - ORGN
  • [3] Metathesis Reactions in Natural Product Fragments and Total Syntheses
    Ahmed, Waqar
    Jayant, Vikrant
    Alvi, Shakeel
    Ahmed, Nadeem
    Ahmed, Azeem
    Ali, Rashid
    ASIAN JOURNAL OF ORGANIC CHEMISTRY, 2022, 11 (04)
  • [4] Total syntheses of the antibacterial natural product abyssomicin C
    Peters, Rene
    Fischer, Daniel F.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (35) : 5736 - 5739
  • [5] Vic-tricarbonyl compounds in natural product synthesis: Studies in total syntheses of preussochromones
    Koert, Ulrich
    Kerste, Eric
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [6] β-lactones:: Intermediates for natural product total synthesis and new transformations
    Wang, YC
    Tennyson, RL
    Romo, D
    HETEROCYCLES, 2004, 64 : 605 - 658
  • [7] Natural product synthesis -: The art of total synthesis
    Markó, IE
    SCIENCE, 2001, 294 (5548) : 1842 - 1843
  • [8] Efficiency in Natural Product Total Synthesis
    Zografos, Alexandros L.
    ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2021, 60 (06) : 2738 - 2739
  • [9] Total synthesis of natural product (±)-aiphanol
    Wang, XL
    Xia, YM
    Feng, JP
    Cao, XP
    Pan, XF
    CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2005, 26 (02): : 259 - 263
  • [10] Enzymes in natural product total synthesis
    Moore, Bradley S.
    Gulder, Tobias A. M.
    NATURAL PRODUCT REPORTS, 2020, 37 (10) : 1292 - 1293
12345