The total syntheses of phorboxazoles - New classics in natural product synthesis

被引：37
|
作者：
Haustedt, LO [1 ]
Hartung, IV [1 ]
Hofftmann, HMR [1 ]
机构：
[1] Univ Hannover, Inst Organ Chem, D-30167 Hannover, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2003年 / 42卷 / 24期
关键词：
antitumor agents; macrolides; phorboxazoles; synthesis design; total synthesis;
D O I：
10.1002/anie.200301643
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The marine sponge metabolites phorboxazoles A (see structural formula) and B were the targets of several clever total syntheses, whose special features are described in this Highlight. Now that the synthetic entry to these compounds has been cleared, their cytostatic activity can be studied thoroughly in vitro and in vivo.
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页码：2711 / 2716
页数：6
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