Merging Chemical Synthesis and Biosynthesis: A New Chapter in the Total Synthesis of Natural Products and Natural Product Libraries

被引:134
|
作者
Kirschning, Andreas [1 ]
Hahn, Frank [1 ]
机构
[1] Leibniz Univ Hannover, Inst Organ Chem & Biomol Wirkstoffzentrum BMWZ, D-30167 Hannover, Germany
关键词
metabolic engineering; mutasynthesis; natural products; semisynthesis; total synthesis; ANTITUMOR AGENT ANSAMITOCIN; COMBINATORIAL BIOSYNTHESIS; GLYCOPEPTIDE ANTIBIOTICS; SUBSTRATE-SPECIFICITY; GENE-CLUSTER; MUTASYNTHESIS; DERIVATIVES; HSP90; SEMISYNTHESIS; CRYPTOPHYCINS;
D O I
10.1002/anie.201107386
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
引用
收藏
页码:4012 / 4022
页数:11
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