Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease

被引：21
|
作者：
Namba, Y
Ouchi, Y
Takeda, A
Ueki, A
Ikeda, K
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Bunkyo Ku, Tokyo 1138655, Japan
[2] Sagami Womens Univ, Dept Biochem, Sagamihara, Japan
[3] Omiya Med Ctr, Jichi Med Sch, Dept Neurobiol, Omiya, Japan
[4] Tokyo Inst Psychiat, Dept Ultrastruct & Histochem, Setagaya Ku, Tokyo, Japan
来源：
BRAIN RESEARCH | 1999年 / 830卷 / 01期
关键词：
bleomycin hydrolase; protease; Alzheimer's disease; senile plaque; immunohistochemistry;
D O I：
10.1016/S0006-8993(99)01435-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Bleomycin hydrolase (BH), a cysteine protease belonging to thr papain superfamily, is one of the candidate beta secretases. We performed immunohistochemical studies of Alzheimer's disease (AD) brains using an antibody to BH. Polyclonal antibody to BH immunostained neocortical neurons. The immunoreactivity was also found in senile plaques in AD. These results may suggest a role of BH in amyloid formation. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：200 / 202
页数：3
相关论文
共 50 条
  • [41] Bleomycin hydrolase is associated with risk of sporadic Alzheimer's disease (vol 18, pg 211, 1998)
    Montoya, SE
    NATURE GENETICS, 1998, 19 (04) : 404 - 404
  • [42] Presenilin immunoreactivity in Alzheimer's disease
    Panegyres, PK
    Toufexis, K
    EUROPEAN JOURNAL OF NEUROLOGY, 2005, 12 (09) : 700 - 706
  • [43] Confocal observation and 3-D reconstruction of senile plaques in Alzheimer's Disease - senile plaque morphology and relationship between senile plaques and astrocytes
    Gondo, T
    Kato, S
    Mitsuno, S
    Hoshii, Y
    Kawano, H
    Setoguchi, M
    Takahashi, M
    Iwata, T
    Ishihara, T
    AMYLOID AND AMYLOIDOSIS 1998, 1999, : 473 - 475
  • [44] Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    Benito, C
    Núñez, E
    Tolón, RM
    Carrier, EJ
    Rábano, A
    Hillard, CJ
    Romero, J
    JOURNAL OF NEUROSCIENCE, 2003, 23 (35): : 11136 - 11141
  • [45] Ubiquilin-1 immunoreactivity is concentrated on Hirano bodies and dystrophic neurites in Alzheimer's disease brains
    Satoh, J.
    Tabunoki, H.
    Ishida, T.
    Saito, Y.
    Arima, K.
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 2013, 39 (07) : 817 - 830
  • [46] Alzheimer's disease: An exacerbation of senile phenoptosis
    Isaev, N. K.
    Stelmashook, E. V.
    Genrikhs, E. E.
    Oborina, M. V.
    Kapkaeva, M. R.
    Skulachev, V. P.
    BIOCHEMISTRY-MOSCOW, 2015, 80 (12) : 1578 - 1581
  • [47] Alzheimer’s disease: An exacerbation of senile phenoptosis
    N. K. Isaev
    E. V. Stelmashook
    E. E. Genrikhs
    M. V. Oborina
    M. R. Kapkaeva
    V. P. Skulachev
    Biochemistry (Moscow), 2015, 80 : 1578 - 1581
  • [48] Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease
    Wang, Ligang
    Sato, Haruhisa
    Zhao, Shiguang
    Tooyama, Ikuo
    NEUROSCIENCE LETTERS, 2010, 481 (03) : 164 - 167
  • [49] Distribution of apolipoprotein E in senile plaques in brains with Alzheimer's disease: Investigation with the confocal laser scan microscope
    Nishiyama, E
    Iwamoto, N
    Ohwada, J
    Arai, H
    BRAIN RESEARCH, 1997, 750 (1-2) : 20 - 24
  • [50] Deranged expression of molecular chaperones in brains of patients with Alzheimer's disease
    Yoo, BC
    Kim, SH
    Cairns, N
    Fountoulakis, M
    Lubec, G
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 280 (01) : 249 - 258
12345