Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease

被引：21
|
作者：
Namba, Y
Ouchi, Y
Takeda, A
Ueki, A
Ikeda, K
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Bunkyo Ku, Tokyo 1138655, Japan
[2] Sagami Womens Univ, Dept Biochem, Sagamihara, Japan
[3] Omiya Med Ctr, Jichi Med Sch, Dept Neurobiol, Omiya, Japan
[4] Tokyo Inst Psychiat, Dept Ultrastruct & Histochem, Setagaya Ku, Tokyo, Japan
来源：
BRAIN RESEARCH | 1999年 / 830卷 / 01期
关键词：
bleomycin hydrolase; protease; Alzheimer's disease; senile plaque; immunohistochemistry;
D O I：
10.1016/S0006-8993(99)01435-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Bleomycin hydrolase (BH), a cysteine protease belonging to thr papain superfamily, is one of the candidate beta secretases. We performed immunohistochemical studies of Alzheimer's disease (AD) brains using an antibody to BH. Polyclonal antibody to BH immunostained neocortical neurons. The immunoreactivity was also found in senile plaques in AD. These results may suggest a role of BH in amyloid formation. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：200 / 202
页数：3
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