Bleomycin hydrolase immunoreactivity in senile plaque in the brains of patients with Alzheimer's disease

被引：21
|
作者：
Namba, Y
Ouchi, Y
Takeda, A
Ueki, A
Ikeda, K
机构：
[1] Univ Tokyo, Grad Sch Med, Dept Geriatr Med, Bunkyo Ku, Tokyo 1138655, Japan
[2] Sagami Womens Univ, Dept Biochem, Sagamihara, Japan
[3] Omiya Med Ctr, Jichi Med Sch, Dept Neurobiol, Omiya, Japan
[4] Tokyo Inst Psychiat, Dept Ultrastruct & Histochem, Setagaya Ku, Tokyo, Japan
来源：
BRAIN RESEARCH | 1999年 / 830卷 / 01期
关键词：
bleomycin hydrolase; protease; Alzheimer's disease; senile plaque; immunohistochemistry;
D O I：
10.1016/S0006-8993(99)01435-3
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Bleomycin hydrolase (BH), a cysteine protease belonging to thr papain superfamily, is one of the candidate beta secretases. We performed immunohistochemical studies of Alzheimer's disease (AD) brains using an antibody to BH. Polyclonal antibody to BH immunostained neocortical neurons. The immunoreactivity was also found in senile plaques in AD. These results may suggest a role of BH in amyloid formation. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：200 / 202
页数：3
相关论文
共 50 条
  • [21] Confocal observation of senile plaques in Alzheimer's disease: Senile plaque morphology and relationship between senile plaques and astrocytes
    Kato, S
    Gondo, T
    Hoshii, Y
    Takahashi, M
    Yamada, M
    Ishihara, T
    PATHOLOGY INTERNATIONAL, 1998, 48 (05) : 332 - 340
  • [22] Astrocytes regulate microglial phagocytosis of senile plaque cores of Alzheimer's disease
    DeWitt, DA
    Perry, G
    Cohen, M
    Doller, C
    Silver, J
    EXPERIMENTAL NEUROLOGY, 1998, 149 (02) : 329 - 340
  • [23] Immunohistological profile of senile plaques in Alzheimer's disease brains and brains of non-demented elderly persons
    Juenemann, M. B. T.
    Eschbach, D. -A.
    da Silva, K.
    Kuchelmeister, K.
    ACTA NEUROPATHOLOGICA, 2008, 116 (03) : 347 - 348
  • [24] Reelin immunoreactivity in the brains of Alzheimer's diseasepatients and Alzheimer model mice
    Takahashi, K.
    Ishida, M.
    Komano, H.
    Takahashi, H.
    EUROPEAN JOURNAL OF NEUROLOGY, 2008, 15 : 232 - 233
  • [25] Analysis of association between bleomycin hydrolase and apolipoprotein E polymorphism in Alzheimer’s disease
    Mohamed Ali Smach
    Bassem Charfeddine
    Turkia Lammouchi
    Leila Ben Othman
    Afef Letaief
    Souhir Nafati
    Hedi Dridi
    Soufien Bennamou
    Khalifa Limem
    Neurological Sciences, 2010, 31 : 687 - 691
  • [26] Analysis of association between bleomycin hydrolase and apolipoprotein E polymorphism in Alzheimer's disease
    Smach, Mohamed Ali
    Charfeddine, Bassem
    Lammouchi, Turkia
    Ben Othman, Leila
    Letaief, Afef
    Nafati, Souhir
    Dridi, Hedi
    Bennamou, Soufien
    Limem, Khalifa
    NEUROLOGICAL SCIENCES, 2010, 31 (06) : 687 - 691
  • [27] Localization of HtrA2/Omi immunoreactivity in brains affected by Alzheimer's disease
    Kawamoto, Yasuhiro
    Ito, Hidefumi
    Kobayashi, Yoshito
    Suzuki, Yasuyuki
    Takahashi, Ryosuke
    NEUROREPORT, 2010, 21 (17) : 1121 - 1125
  • [28] Regional and cellular distribution of bleomycin hydrolase mRNA in human brain: comparison between Alzheimer's diseased and control brains
    Malherbe, P
    Faull, RLM
    Richards, JG
    NEUROSCIENCE LETTERS, 2000, 281 (01) : 37 - 40
  • [29] Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease
    Yamada, T
    Tsujioka, Y
    Taguchi, J
    Takahashi, M
    Tsuboi, Y
    Moroo, I
    Yang, J
    Jefferies, WA
    BRAIN RESEARCH, 1999, 845 (01) : 1 - 5
  • [30] Lack of association between bleomycin hydrolase gene polymorphism and Alzheimer's disease in Japanese people
    Namba, Y
    Ouchi, Y
    Asada, T
    Hattori, H
    Ueki, A
    Ikeda, K
    ANNALS OF NEUROLOGY, 1999, 46 (01) : 136 - 137
12345