Bronsted Acid-Catalyzed Four-Component Cascade Reaction: Facile Synthesis of Hexahydroimidazo[1,2-a]pyridines

被引：20
|
作者：
Wang, Ren-Lin [1 ]
Zhu, Ping [1 ]
Lu, Yu [1 ]
Huang, Fu-Ping [1 ]
Hui, Xin-Ping [1 ]
机构：
[1] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Bronsted acids; ethane-1; 2-diamine; imidazo[1; 2-a]pyridines; multicomponent cascade reaction; MULTICOMPONENT REACTIONS; EFFICIENT SYNTHESIS; PASSERINI REACTION; ANTIULCER AGENTS; C-NUCLEOSIDES; UGI; ROUTE; FUNCTIONALIZATION; HETEROCYCLES; DERIVATIVES;
D O I：
10.1002/adsc.201200145
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient four-component cascade reaction for the synthesis of trisubstituted hexahydroimidazo[1,2-a]pyridines starting from readily available aldehydes, ketones and ethane-1,2-diamine catalyzed by p-toluenesulfonic acid is described. Two new cycles and five new bonds are constructed with all reactants being efficiently utilized in this transformation. The mechanism of the reaction was investigated and some crucial reaction intermediates were observed.
引用
收藏
页码：87 / 92
页数：6
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